Tcirg1^tm1.2Ywd
Targeted Allele Detail

Summary

• Symbol: Tcirg1^tm1.2Ywd
• Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1.2, Yoh Wada
• MGI ID: MGI:3852642
• Synonyms: a3 mutant, Tcirg1^delta
• Gene: Tcirg1 Location: Chr19:3946050-3957133 bp, - strand Genetic Position: Chr19, 3.62 cM
• Alliance: Tcirg1^tm1.2Ywd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150327
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The gene is truncated after exon 13. It contains a single FRT site and a single loxP site in the remaining exon 13-proximal segment of intron 13. Immunoblot analysis fails to detect the a3 subunit of vacuolar-type ATPase (V-ATPase), which is encoded by the endogenous gene, in liver lysates of homozygous mutant mice. (J:150327)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcirg1 Mutation: 35 strains or lines available

References

• Original: J:150327 Sun-Wada GH, et al., Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification. J Cell Sci. 2009 Jul 15;122(Pt 14):2504-13
• All: 6 reference(s)