Cop1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cop1
COP1, E3 ubiquitin ligase
MGI:1347046

18 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cop1^{Gt(XR0177)Wtsi}/Cop1^{Gt(XR0177)Wtsi} involves: 129P2/OlaHsd	abnormal heart development	J:178271
	embryonic lethality during organogenesis, complete penetrance	J:178271
Cop1^{Gt(XR0653)1.1Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi} involves: 129P2/OlaHsd * C57BL/6 * CBA	belly spot	J:178271
	decreased body weight	J:178271
	increased B cell derived lymphoma incidence	J:178271
	increased histiocytic sarcoma incidence	J:178271
	increased incidence of induced tumors	J:178271
	increased T cell derived lymphoma incidence	J:178271
	increased testicular teratoma incidence	J:178271
	increased tumor incidence	J:178271
	increased uterus tumor incidence	J:178271
Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi} involves: 129P2/OlaHsd * C57BL/6 * CBA	anemia	J:178271
	hydrops fetalis	J:178271
	lethality throughout fetal growth and development, incomplete penetrance	J:178271
Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)Wtsi} involves: 129P2/OlaHsd	abnormal heart development	J:178271
	embryonic lethality during organogenesis, complete penetrance	J:178271
Cop1^tm1.1Vmd/Cop1^tm2.1Vmd Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6 C57BL/6N * CBA	abnormal prostate gland physiology	J:172653
Cop1^tm2.1Vmd/Cop1⁺ Tg(Pbsn-cre)4Prb/0 B6N.Cg-Cop1^tm2.1Vmd Tg(Pbsn-cre)4Prb	prostate gland hyperplasia	J:172653
Cop1^tm2.1Vmd/Cop1⁺ Tg(Pbsn-cre)4Prb/0 B6N.CgCop1^tm2.1Vmd Pten^tm1Hwu Tg(Pbsn-cre)4Prb	increased prostate gland adenocarcinoma incidence	J:172653
	increased prostate intraepithelial neoplasia incidence	J:172653
Cop1^tm2.1Vmd/Cop1^tm2.1Vmd Tg(Pbsn-cre)4Prb/0 B6N.Cg-Cop1^tm2.1Vmd Tg(Pbsn-cre)4Prb	abnormal prostate gland physiology	J:172653
	increased prostate intraepithelial neoplasia incidence	J:172653
	prostate gland hyperplasia	J:172653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23