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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mbd4
methyl-CpG binding domain protein 4
MGI:1333850
30 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mbd4/Ift122tm1Abc/Mbd4+
B6.129-Mbd4/Ift122tm1Abc
decreased embryonic cilium length J:143544
Mbd4/Ift122tm1Abc/Mbd4/Ift122tm1Abc
B6.129-Mbd4/Ift122tm1Abc
abnormal abdominal wall morphology J:143544
abnormal cilium morphology J:143544
abnormal direction of heart looping J:143544
abnormal eye development J:143544
abnormal head morphology J:143544
abnormal left-right axis patterning J:143544
abnormal limb development J:143544
abnormal neural tube morphology J:143544
abnormal pharyngeal arch development J:143544
abnormal ventral interneuron 3 morphology J:143544
absent embryonic cilia J:143544
delayed embryo turning J:143544
delayed limb development J:143544
ectrodactyly J:143544
elongated neck J:143544
embryonic lethality during organogenesis, complete penetrance J:143544
enlarged heart J:143544
exencephaly J:143544
hemorrhage J:143544
increased motor neuron number J:143544
open neural tube J:143544
polysyndactyly J:143544
right-sided stomach J:143544
situs inversus J:143544
Mbd4/Ift122tm1Abc/Mbd4/Ift122tm1Abc
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
abnormal cell cycle checkpoint function J:86981
decreased physiological sensitivity to xenobiotic J:86981
decreased sensitivity to induced cell death J:86981
Mbd4tm1Bird/Mbd4tm1Bird
involves: 129P2/OlaHsd * C57BL/6
abnormal cell physiology J:77896
Mbd4tm1Wed/Mbd4tm1Wed
B6.Cg-Mbd4tm1Wed/J
abnormal DNA methylation J:175891
Mbd4tm1Wed/Mbd4tm1Wed
involves: 129/Sv * C57BL/6 * SJL
abnormal cell physiology J:80319
Mbd4tm2Abc/Mbd4tm2Abc
involves: 129/Sv * 129X1/SvJ * C57BL/6
abnormal cell cycle checkpoint function J:86981
decreased physiological sensitivity to xenobiotic J:86981
decreased sensitivity to induced cell death J:86981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory