115 phenotypes from 6 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Apaf1fog/Apaf1fog involves: C3H/HeJ	abnormal cerebral hemisphere morphology	J:41353
	abnormal cranial flexure morphology	J:41353
	abnormal cranium morphology	J:41353
	abnormal embryonic neuroepithelium morphology	J:41353
	abnormal forebrain morphology	J:41353
	abnormal forehead shape	J:41353
	abnormal lateral ventricle morphology	J:41353
	abnormal neurocranium morphology	J:41353
	abnormal telencephalon morphology	J:41353
	curly tail	J:41353
	decreased survivor rate	J:41353
	delayed neural tube closure	J:41353
	exencephaly	J:41353, J:131954
	intracerebral hemorrhage	J:41353
	kinked tail	J:41353
	midline facial cleft	J:41353
	normal nervous system phenotype	J:131954
	perinatal lethality, incomplete penetrance	J:41353
	postnatal lethality, incomplete penetrance	J:41353
	reduced female fertility	J:41353
	reduced male fertility	J:41353
	short snout	J:41353
	spina bifida	J:131954
	spina bifida occulta	J:41353
Apaf1fog/Apaf1Gt(IRESBetageo)XIX18Pgr involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeJ * NMRI	abnormal neuron morphology	J:131954
	decreased neuron apoptosis	J:131954
	motor neuron degeneration	J:131954
Apaf1fog/Apaf1tm1Her involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6b	abnormal neural tube morphology	J:71086
	cranioschisis	J:71086
	exencephaly	J:71086
Apaf1fog/Apaf1tm1Mak involves: 129S6/SvEvTac * C3H/HeJ * CD-1	abnormal neuron morphology	J:131954
	decreased neuron apoptosis	J:131954
	motor neuron degeneration	J:131954
Apaf1fog/Apaf1ytj involves: C3H/HeJ * C57BL/6J	abnormal craniofacial morphology	J:201947
	abnormal forebrain development	J:201947
	abnormal fourth ventricle morphology	J:201947
	abnormal vertebrae morphology	J:201947
	broad face	J:201947
	encephalomeningocele	J:201947
	exencephaly	J:201947
	facial cleft	J:201947
	kinked tail	J:201947
	spina bifida	J:201947
Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr involves: 129/Sv * 129X1/SvJ	abnormal apoptosis	J:103480
Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr involves: 129S1/Sv * 129X1/SvJ	decreased neuron apoptosis	J:112874
	increased neuron apoptosis	J:112874
Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr involves: 129S1/Sv * 129X1/SvJ * NMRI	abnormal brain development	J:49840
	abnormal brain morphology	J:49840
	abnormal cortical marginal zone morphology	J:49840
	abnormal craniofacial bone morphology	J:49840
	abnormal embryonic neuroepithelial layer differentiation	J:49840
	abnormal embryonic tissue morphology	J:49840
	abnormal folding of telencephalic vesicles	J:49840
	abnormal lens polarity	J:49840
	abnormal neuron morphology	J:131954
	abnormal neuron physiology	J:131954
	absent ethmoid bone	J:49840
	absent neurocranium	J:49840
	absent vomer bone	J:49840
	choroid plexus hyperplasia	J:49840
	decreased fibroblast apoptosis	J:49840
	diencephalon hyperplasia	J:49840
	exencephaly	J:49840, J:131954
	hydrocephaly	J:49840
	hypothalamus hyperplasia	J:49840
	impaired ossification of basisphenoid bone	J:49840
	interdigital webbing	J:49840
	lethality throughout fetal growth and development, complete penetrance	J:49840
	midbrain hyperplasia	J:49840
	midline facial cleft	J:49840
	normal nervous system phenotype	J:49840
	persistence of hyaloid vascular system	J:49840
	persistence of medial edge epithelium during palatal shelf fusion	J:49840
	retina fold	J:49840
	retina hyperplasia	J:49840
	small embryonic telencephalon	J:49840
	small lens	J:49840
Apaf1tm1Her/Apaf1tm1Her involves: 129S6/SvEvTac * C57BL/6J	abnormal brain ventricle morphology	J:60409
	abnormal embryonic/fetal subventricular zone morphology	J:60409
	abnormal fibroblast apoptosis	J:60409
	abnormal lateral ventricle morphology	J:60409
	abnormal nasal septum morphology	J:60409
	abnormal neuron differentiation	J:60409
	abnormal neuronal migration	J:60409
	abnormal otic vesicle development	J:60409
	abnormal palate morphology	J:60409
	abnormal retina neuronal layer morphology	J:60409
	abnormal seminiferous tubule morphology	J:60409
	abnormal spermatogonia morphology	J:60409
	abnormal viscerocranium morphology	J:60409
	azoospermia	J:60409
	cranioschisis	J:60409
	decreased neuron apoptosis	J:60409
	exencephaly	J:60409
	hydrocephaly	J:60409
	hyperactivity	J:60409
	increased embryonic neuroepithelium thickness	J:60409
	increased locomotor activity	J:60409
	male infertility	J:60409
	normal neoplasm	J:60409
	open neural tube	J:60409
	perinatal lethality, incomplete penetrance	J:60409
	premature death	J:60409
	reduced female fertility	J:60409
Apaf1tm1Hez/Apaf1tm1Hez involves: 129 * C57BL/6 * C57BL/6J	no abnormal phenotype detected	J:179045
Apaf1tm1Mak/Apaf1tm1Mak either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)	abnormal craniofacial morphology	J:49841
	abnormal digit morphology	J:49841
	abnormal facial morphology	J:49841
	abnormal forebrain morphology	J:49841
	abnormal frontal bone morphology	J:49841
	abnormal head shape	J:49841
	abnormal hindbrain morphology	J:49841
	abnormal hypothalamus morphology	J:49841
	abnormal respiratory electron transport chain	J:49841
	abnormal thalamus morphology	J:49841
	abnormal third ventricle morphology	J:49841
	choroid plexus hyperplasia	J:49841
	decreased apoptosis	J:49841
	decreased sensitivity to induced cell death	J:49841
	exencephaly	J:49841
	flat head	J:49841
	normal hearing/vestibular/ear phenotype	J:98518
	hydrocephaly	J:49841
	hypothalamus hyperplasia	J:49841
	normal immune system phenotype	J:49841
	increased cell proliferation	J:49841
	interdigital webbing	J:49841
	lethality throughout fetal growth and development, incomplete penetrance	J:49841
	microcephaly	J:49841
	perinatal lethality, incomplete penetrance	J:49841
	postnatal lethality, complete penetrance	J:49841
	thalamus hyperplasia	J:49841
	thickened cerebral cortex	J:49841
Apaf1tm1Mak/Apaf1tm1Mak involves: 129P2/OlaHsd * CD-1	abnormal neuron morphology	J:131954
	abnormal neuron physiology	J:131954
	exencephaly	J:131954
	normal nervous system phenotype	J:131954
Apaf1ytj/Apaf1ytj involves: C3H/HeJ * C57BL/6J	abnormal craniofacial morphology	J:201947
	abnormal forebrain development	J:201947
	abnormal frontal bone morphology	J:201947
	abnormal maxilla morphology	J:201947
	abnormal presphenoid bone morphology	J:201947
	absent interparietal bone	J:201947
	absent parietal bone	J:201947
	absent presphenoid bone	J:201947
	absent supraoccipital bone	J:201947
	broad frontonasal prominence	J:201947
	exencephaly	J:201947
	failure of eyelid fusion	J:201947
	interdigital webbing	J:201947
	midline facial cleft	J:201947
	normal nervous system phenotype	J:201947
	perinatal lethality, complete penetrance	J:201947