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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hap1
huntingtin-associated protein 1
MGI:1261831
33 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hap1tm1b(KOMP)Wtsi/Hap1tm1b(KOMP)Wtsi
C57BL/6N-Hap1tm1b(KOMP)Wtsi/J 		preweaning lethality, complete penetrance J:211773
Hap1tm1Hay/Hap1tm1Hay
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal cerebral cortex morphology J:76174
abnormal eating behavior J:76174
absent gastric milk in neonates J:76174
decreased body size J:76174
decreased body weight J:76174
decreased brain size J:76174
decreased brain weight J:76174
decreased circulating leptin level J:76174
dehydration J:76174
dry skin J:76174
loose skin J:76174
pallor J:76174
postnatal lethality, complete penetrance J:76174
slow postnatal weight gain J:76174
thin cerebral cortex J:76174
Hap1tm1Id/Hap1tm1Id
involves: 129 * C57BL/6 		abnormal suckling behavior J:94581
absent gastric milk in neonates J:94581
postnatal growth retardation J:94581
postnatal lethality, incomplete penetrance J:94581
Hap1tm1Id/Hap1tm2Id
involves: 129S1/Sv * C57BL/6 		abnormal suckling behavior J:94581
postnatal growth retardation J:94581
postnatal lethality, complete penetrance J:94581
Hap1tm1Id/Hap1tm2Id
Tg(Camk2a-cre)2Szi/0
involves: 129S1/Sv * C57BL/6 * CBA 		postnatal growth retardation J:94581
Hap1tm1Xjl/Hap1tm1Xjl
involves: 129S6/SvEvTac * Black Swiss 		abnormal hypothalamus morphology J:84682
abnormal paraventricular hypothalamic nucleus morphology J:84682
abnormal ventromedial hypothalamic nucleus morphology J:84682
absent gastric milk in neonates J:84682
normal behavior/neurological phenotype J:84682
neurodegeneration J:84682
postnatal lethality, complete penetrance J:84682
slow postnatal weight gain J:84682
Hap1tm1Xjl/Hap1tm1Xjl
involves: 129S6/SvEvTac * C57BL/6 		abnormal vesicle-mediated transport J:213185
Hap1tm2Id/Hap1tm2Id
involves: 129S1/Sv * C57BL/6 		abnormal suckling behavior J:94581
postnatal growth retardation J:94581
postnatal lethality, complete penetrance J:94581
Hap1tm2Xjl/Hap1tm2Xjl
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA 		abnormal neuron proliferation J:224698
decreased coping response J:224698
decreased locomotor activity J:224698
impaired neuron differentiation J:224698
Hap1tm2Xjl/Hap1tm2Xjl
Tg(Camk2a-cre)159Kln/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6 		abnormal motor coordination/balance J:224698
abnormal neuron proliferation J:224698
anhedonia J:224698
decreased body weight J:224698
decreased coping response J:224698
Hap1tm2Xjl/Hap1tm2Xjl
Tg(HCRT-cre)1Stak/0
involves: 129 * C57BL/6 * DBA/1 		abnormal hypothalamus morphology J:163896
abnormal neurite morphology J:163896
decreased body weight J:163896
decreased food intake J:163896
decreased locomotor activity J:163896
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory