Tg(HCRT-cre)1Stak
Transgene Detail

Summary

• Symbol: Tg(HCRT-cre)1Stak
• Name: transgene insertion 1, Takeshi Sakurai
• MGI ID: MGI:3839422
• Synonyms: orexin-Cre, orx-Cre
• Transgene: Tg(HCRT-cre)1Stak Location: unknown
• Alliance: Tg(HCRT-cre)1Stak page

Transgene origin

• Strain of Origin: DBA/1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(HCRT-cre)1Stak expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  HCRT (3060)

  Hcrt	(MGI:1202306)

• Mutation details: A 3.2 kb fragment of the 5' upstream region of the human HCRT gene drives expression of cre and eGFP. The eGFP gene is separated from the cre gene by an IRES element. Cre activity was confirmed in most orexin containing neurons; however, no GFP expression was detected. (J:146778)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	HCRT (human) Summary of all recombinase alleles driven by HCRT. Comparative matrix view of recombinase activities Alliance human HCRT gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146778 Matsuki T, et al., Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64
• All: 16 reference(s)