Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm2Xjl mutation
(0 available);
any
Hap1 mutation
(37 available)
Tg(HCRT-cre)1Stak mutation
(0 available)
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Reduced body weight in Hap1tm2Xjl/Hap1tm2Xjl Tg(HCRT-cre)1Stak/0 mice
growth/size/body
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• the greatest differences are seen at the ages of 2?4 weeks
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behavior/neurological
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• males and females consume 66 and 50%, respectively, of the food that control mice eat
• however, water consumption is normal
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• show less activity than the control mice at night, with females showing a greater difference
• show less activity in response to fasting-induced metabolic stress
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nervous system
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• orexin neurons of the brain display disrupted or fragmented neurites in the dorsomedial hypothalamic and lateral hypothalamic nuclei
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabbr1tm2Bet mutation
(0 available);
any
Gabbr1 mutation
(71 available)
Tg(HCRT-cre)1Stak mutation
(0 available)
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nervous system
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• despite loss of Gabbr1 expression, no decrease in the number of orexin positive neurons is detected and spontaneous excitatory postsynaptic currents in orexin neurons are similar to controls
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• unlike in controls, treatment with bicuculline induces depolarization of orexin neurons
• membrane resistance of orexin neurons is significantly decreased
• glutamate and GABA-A agonists are less potent in inducing depolarizing currents in orexin neurons compared to controls
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• increase in the frequency of fast spontaneous inhibitory postsynaptic currents in orexin neurons compared to control littermates
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behavior/neurological
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• severe fragmentation of the sleep wake cycle with decreased awake, non-REM, and REM sleep episode durations and reduced REM latency
• fragmentation occurs in both the light and dark phases
• the delta power is significantly increased in non-REM sleep and the theta power is decreased during REM sleep compared to controls
• however, the overall amounts of wakefulness, non-REM and REM sleep are similar to controls
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