Ifnb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ifnb1
interferon beta 1, fibroblast
MGI:107657

46 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp B6.129P2-Ifnb1^tm1Acgp	abnormal macrophage physiology	J:136368
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp B6.129P2-Ifnb1^tm1Acgp	decreased interleukin-1 beta secretion	J:136368
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp involves: 129P2/OlaHsd	abnormal spleen primary B follicle morphology	J:86527
	decreased common myeloid progenitor cell number	J:86527
	decreased erythroid progenitor cell number	J:86527
	decreased macrophage cell number	J:86527
	decreased mature B cell number	J:86527
	decreased monocyte cell number	J:86527
	decreased neutrophil cell number	J:86527
	decreased pro-B cell number	J:86527
	decreased tumor necrosis factor secretion	J:86527
	increased T cell proliferation	J:86527
	increased tumor growth/size	J:86527
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp involves: 129P2/OlaHsd * C57BL/6	decreased circulating interferon-beta level	J:61048
	increased susceptibility to Poxviridae infection	J:61048
Ifnb1^tm1Lky/Ifnb1^tm1Lky involves: 129 * C57BL/6	no abnormal phenotype detected	J:152138
Ifnb1^tm1Tl/Ifnb1^tm1Tl B6.129P2-Ifnb1^tm1Tl	decreased circulating interferon-alpha level	J:172226
	decreased circulating interferon-beta level	J:172226
	decreased susceptibility to bacterial infection	J:172226
Ifnb1^tm1Tl/Ifnb1^tm1Tl B10.129P2-Ifnb1^tm1Tl	abnormal macrophage physiology	J:83021
	abnormal microglial cell physiology	J:83021
	CNS inflammation	J:83021
	demyelination	J:83021
	increased interferon-gamma secretion	J:83021
	increased interleukin-4 secretion	J:83021
	increased susceptibility to experimental autoimmune encephalomyelitis	J:83021
	increased tumor necrosis factor secretion	J:83021
Ifnb1^tm1Ttg/Ifnb1^tm1Ttg B6.Cg-Ifnb1^tm1Ttg	abnormal osteoclast morphology	J:76097
Ifnb1^tm1Ttg/Ifnb1^tm1Ttg B6.Cg-Ifnb1^tm1Ttg	decreased bone mineral density	J:76097
Ifnb1^tm1Ttg/Ifnb1^tm1Ttg involves: C57BL/6	abnormal response to infection	J:116703
Tg(CAG-C1qtnf6)#Yiw/0 involves: C57BL/6JJcl	abnormal complement protein level	J:227217
	decreased IgG level	J:227217
	decreased susceptibility to induced arthritis	J:227217
	impaired complement alternative pathway	J:227217
	normal renal/urinary system phenotype	J:227217
Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif C3H/HeOuJ-Tg(H2-K1-Ifnb1)10Seif	abnormal male germ cell apoptosis	J:174828
	abnormal male reproductive system physiology	J:174828
	abnormal seminiferous tubule morphology	J:174828
	abnormal spermiogenesis	J:174828
	abnormal testis morphology	J:174828
	decreased litter size	J:174828
	decreased testis weight	J:174828
	early reproductive senescence	J:174828
	male infertility	J:174828
	oligozoospermia	J:174828
	reduced male fertility	J:174828
	normal reproductive system phenotype	J:174828
	seminiferous tubule degeneration	J:174828

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23