Ifnb1tm1Acgp
Targeted Allele Detail
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Symbol: |
Ifnb1tm1Acgp |
Name: |
interferon beta 1, fibroblast; targeted mutation 1, Andrew C G Porter |
MGI ID: |
MGI:2386955 |
Synonyms: |
IFN-beta- |
Gene: |
Ifnb1 Location: Chr4:88440262-88441011 bp, - strand Genetic Position: Chr4, 41.91 cM
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Alliance: |
Ifnb1tm1Acgp page
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Germline Transmission: |
Earliest citation of germline transmission:
J:61048
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Parent Cell Line: |
HM-1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The coding region of the gene was deleted and replaced with a GFP-neo-loxP cassette via homologous recombination. The targeted mutation places the green fluorescent protein gene under the control of the endogenous promoter. RT-PCR analysis of mouse embryonic fibroblasts derived from homozygous mutant animals verified the absence of Ifnb expression and presence of GFP transcripts.
(J:61048)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ifnb1 Mutation: |
20 strains or lines available
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Original: |
J:61048 Deonarain R, et al., Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol. 2000 Apr;74(7):3404-9 |
All: |
20 reference(s) |
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