Rnasek Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rnasek
ribonuclease, RNase K
MGI:106369

11 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rnasek^em1Xlt/Rnasek^em1Xlt involves: C57BL/6J	abnormal lysosome physiology	J:386262
	decreased cell proliferation	J:386262
	decreased embryo size	J:386262
	decreased embryonic epiblast cell proliferation	J:386262
	early cellular replicative senescence	J:386262
	embryonic growth arrest	J:386262
	embryonic lethality between implantation and somite formation, complete penetrance	J:386262
	impaired autophagy	J:386262
	increased embryonic epiblast cell apoptosis	J:386262
Rnasek^{tm1b(EUCOMM)Wtsi}/Rnasek⁺ C57BL/6N-Rnasek^{tm1b(EUCOMM)Wtsi}/Wtsi	increased circulating alanine transaminase level	J:211773
Rnasek^{tm1b(EUCOMM)Wtsi}/Rnasek^{tm1b(EUCOMM)Wtsi} C57BL/6N-Rnasek^{tm1b(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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