Rnasek^em1Xlt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnasek^em1Xlt
• Name: ribonuclease, RNase K; endonuclease-mediated mutation 1, Xiao-Li Tian
• MGI ID: MGI:8401752
• Gene: Rnasek Location: Chr11:70128950-70130668 bp, - strand Genetic Position: Chr11, 42.99 cM
• Alliance: Rnasek^em1Xlt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination targeting a PAM site in exon 1 resulted in a 5bp deletion producing a frameshift mutation. The mutant allele is predicted to produce a truncated 20-amino acid peptide. (J:386262)

• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnasek Mutation: 10 strains or lines available

References

• Original: J:386262 Wan M, et al., Loss of RNASEK Terminates Egg Cylinder Development by Impairing Lysosomal Function Associated With V-ATPase in Mouse. FASEB J. 2025 Dec 31;39(24):e71332
• All: 1 reference(s)