98 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Umod)416Lura/0 involves: FVB	no abnormal phenotype detected	J:161532
Tg(Umod*C147W)958Lura/0 involves: FVB	abnormal kidney morphology	J:161532
	abnormal renal tubule morphology	J:161532
	abnormal renal/urinary system physiology	J:161532
	decreased urine osmolality	J:161532
	decreased urine pH	J:161532
	dilated renal tubule	J:161532
	increased blood osmolality	J:161532
	increased blood urea nitrogen level	J:161532
	increased circulating antidiuretic hormone level	J:161532
	increased circulating creatinine level	J:161532
	increased kidney cell proliferation	J:161532
	increased urine calcium level	J:161532
	isosthenuria	J:161532
	kidney corticomedullary cyst	J:161532
	kidney failure	J:161532
	kidney inflammation	J:161532
	polydipsia	J:161532
	polyuria	J:161532
	renal cast	J:161532
	renal interstitial fibrosis	J:161532
	renal tubular necrosis	J:161532
	renal tubule atrophy	J:161532
Umodem1Duf/Umod+ C57BL/6J-Umodem1Duf	abnormal autophagy	J:252597
	abnormal proximal convoluted tubule morphology	J:252597
	decreased body weight	J:252597
	decreased kidney weight	J:252597
	increased blood urea nitrogen level	J:252597
	increased circulating creatinine level	J:252597
	increased endoplasmic reticulum stress	J:252597
	increased kidney apoptosis	J:252597
	isosthenuria	J:252597
	kidney failure	J:252597
	kidney inflammation	J:252597
	renal interstitial fibrosis	J:252597
Umodtm1.1Rvt/Umod+ either: B6J.129-Umodtm1.1Rvt or (involves: 129S1/Sv * 129X1/SvJ)	decreased urine osmolality	J:242593
	decreased urine pH	J:242593
	decreased urine protein level	J:242593
	decreased urine uric acid level	J:242593
	increased blood osmolality	J:242593
	increased blood urea nitrogen level	J:242593
	increased circulating creatinine level	J:242593
	increased urine calcium level	J:242593
	kidney failure	J:242593
	kidney inflammation	J:242593
	polyuria	J:242593
	renal interstitial fibrosis	J:242593
Umodtm1.1Rvt/Umodtm1.1Rvt either: B6J.129-Umodtm1.1Rvt or (involves: 129S1/Sv * 129X1/SvJ)	abnormal renal tubule morphology	J:242593
	decreased urine osmolality	J:242593
	decreased urine pH	J:242593
	decreased urine protein level	J:242593
	decreased urine uric acid level	J:242593
	glomerulosclerosis	J:242593
	increased alkaline phosphatase activity	J:242593
	increased blood osmolality	J:242593
	increased blood urea nitrogen level	J:242593
	increased circulating calcium level	J:242593
	increased circulating creatinine level	J:242593
	increased urine calcium level	J:242593
	kidney failure	J:242593
	kidney inflammation	J:242593
	polyuria	J:242593
	renal interstitial fibrosis	J:242593
Umodtm1Kuma/Umodtm1Kuma involves: 129	abnormal juxtaglomerular apparatus morphology	J:96653
	abnormal kidney morphology	J:245853
	abnormal loop of Henle ascending limb thick segment morphology	J:96653
	abnormal urine homeostasis	J:245853
	abnormal urine osmolality	J:96653
	decreased creatinine clearance	J:96653, J:245853
	decreased renal glomerular filtration rate	J:96653, J:245853
	decreased susceptibility to hypertension	J:245853
	decreased systemic arterial systolic blood pressure	J:245853
	increased creatinine clearance	J:245853
	increased fluid intake	J:245853
	increased renal glomerular filtration rate	J:245853
	increased urine chloride ion level	J:245853
	increased urine potassium level	J:245853
	increased urine sodium level	J:245853
	polyuria	J:96653, J:245853
	weight loss	J:245853
Umodtm1Xrw/Umod+ B6.129S6-Umodtm1Xrw	hydronephrosis	J:163552
	nephrocalcinosis	J:163552
	urolithiasis	J:163552
Umodtm1Xrw/Umodtm1Xrw 129S/SvEv-Umodtm1Xrw	abnormal kidney papilla morphology	J:163552
	abnormal papillary duct morphology	J:163552
	abnormal urine homeostasis	J:127526, J:163552
	abnormal urine organic anion level	J:163552
	crystalluria	J:127526
	decreased urine citrate level	J:163552
	decreased urine flow rate	J:163552
	decreased urine pH	J:163552
	dilated kidney collecting duct	J:127526, J:163552
	hydronephrosis	J:163552
	increased urine ammonia level	J:163552
	increased urine calcium level	J:163552
	increased urine chloride ion level	J:127526, J:163552
	increased urine creatinine level	J:163552
	increased urine magnesium level	J:163552
	increased urine phosphate level	J:127526, J:163552
	increased urine potassium level	J:163552
	increased urine sodium level	J:127526
	increased urine uric acid level	J:163552
	nephrocalcinosis	J:127526, J:163552
	renal fibrosis	J:127526
	urolithiasis	J:163552
Umodtm1Xrw/Umodtm1Xrw B6.129S6-Umodtm1Xrw	abnormal kidney papilla morphology	J:163552
	abnormal papillary duct morphology	J:163552
	dilated kidney collecting duct	J:163552
	hydronephrosis	J:163552
	nephrocalcinosis	J:163552
	urolithiasis	J:163552
Umodtm1Xrw/Umodtm1Xrw involves: 129S6/SvEvTac	increased susceptibility to bacterial infection	J:95431
UmodUrehd1/Umod+ C3HeB/FeJ-UmodUrehd1	decreased body weight	J:121470
	decreased circulating glucose level	J:121470
	decreased renal glomerular filtration rate	J:121470
	decreased total body fat amount	J:121470
	decreased urine creatinine level	J:121470
	decreased urine sodium level	J:121470
	increased blood urea nitrogen level	J:121470
	increased circulating creatinine level	J:121470
	increased fluid intake	J:121470
	increased food intake	J:121470
	increased urine potassium level	J:121470
	polyuria	J:121470
UmodUrehd1/Umod+ involves: C3HeB/FeJ	abnormal endoplasmic reticulum morphology	J:201084
	abnormal loop of Henle ascending limb thick segment morphology	J:201084
	abnormal urine urea nitrogen level	J:201084
	decreased body weight	J:201084
	decreased bone mineral content	J:201084
	decreased bone mineral density	J:201084
	decreased circulating cholesterol level	J:201084
	decreased circulating ferritin level	J:201084
	decreased circulating iron level	J:201084
	decreased circulating phosphate level	J:201084
	decreased circulating transferrin level	J:201084
	decreased circulating triglyceride level	J:201084
	decreased total body fat amount	J:201084
	decreased urine osmolality	J:201084
	decreased urine uric acid level	J:201084
	dilated renal glomerular capsule	J:201084
	normal homeostasis/metabolism phenotype	J:201084
	hydronephrosis	J:201084
	increased blood urea nitrogen level	J:201084
	increased circulating alkaline phosphatase level	J:201084
	increased circulating calcium level	J:201084
	increased circulating creatinine level	J:201084
	increased circulating potassium level	J:201084
	increased urine calcium level	J:201084
	increased urine chloride ion level	J:201084
	increased urine flow rate	J:201084
	increased urine magnesium level	J:201084
	increased urine potassium level	J:201084
	increased urine sodium level	J:201084
	renal glomerulus cyst	J:201084
	renal interstitial fibrosis	J:201084
	renal tubular necrosis	J:201084
UmodUrehd1/UmodUrehd1 involves: C3HeB/FeJ	decreased body weight	J:201084
	decreased renal glomerular filtration rate	J:201084
	increased blood urea nitrogen level	J:201084
	renal interstitial fibrosis	J:201084
	renal tubular necrosis	J:201084
Umodurehr4/Umod+ C3HeB/FeJ-Umodurehr4	abnormal blood homeostasis	J:153895
	abnormal circulating lipid level	J:153895
	decreased basal metabolism	J:153895
	decreased body temperature	J:153895
	decreased body weight	J:153895
	decreased bone mineral content	J:153895
	decreased bone mineral density	J:153895
	decreased circulating cholesterol level	J:153895
	decreased circulating triglyceride level	J:153895
	decreased percent body fat/body weight	J:153895
	decreased total body fat amount	J:153895
	increased blood urea nitrogen level	J:201084
	increased circulating creatinine level	J:153895
	increased lean body mass	J:153895
	renal interstitial fibrosis	J:201084
	renal tubular necrosis	J:201084
Umodurehr4/Umodurehr4 C3HeB/FeJ-Umodurehr4	abnormal blood homeostasis	J:153895
	abnormal bone structure	J:153895
	abnormal circulating lipid level	J:153895
	abnormal urine homeostasis	J:153895
	decreased basal metabolism	J:153895
	decreased body temperature	J:153895
	decreased body weight	J:153895
	decreased bone mineral content	J:153895
	decreased bone mineral density	J:153895
	decreased bone mineral density of femur	J:153895
	decreased circulating cholesterol level	J:153895
	decreased circulating triglyceride level	J:153895
	decreased percent body fat/body weight	J:153895
	decreased total body fat amount	J:153895
	decreased urine osmolality	J:153895
	decreased urine sodium level	J:121470
	increased blood urea nitrogen level	J:121470
	increased blood uric acid level	J:153895
	increased circulating calcium level	J:153895
	increased circulating creatinine level	J:121470, J:153895
	increased lean body mass	J:153895
	increased urine potassium level	J:153895
	increased urine sodium level	J:153895
	polyuria	J:153895
	normal renal/urinary system phenotype	J:153895
	uremia	J:153895