GO Annotations Graph

• Symbol: Mark2
• Name: MAP/microtubule affinity regulating kinase 2
• ID: MGI:99638

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0048156	tau protein binding	ISO	J:155856
Molecular Function	GO:0050321	tau-protein kinase activity	ISO	J:155856
Molecular Function	GO:0050321	tau-protein kinase activity	ISO	J:164563
Molecular Function	GO:0050321	tau-protein kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0045180	basal cortex	IDA	J:99397
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326642
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326642
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326642
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0097427	microtubule bundle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:99397
Cellular Component	GO:0005634	nucleus	IDA	J:99397
Cellular Component	GO:0005634	nucleus	IDA	J:99397
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	IDA	J:326642
Cellular Component	GO:0098794	postsynapse	IDA	J:326642
Cellular Component	GO:0098794	postsynapse	IDA	J:326642
Biological Process	GO:0061564	axon development	ISO	J:155856
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0030010	establishment of cell polarity	ISO	J:164563
Biological Process	GO:0071963	establishment or maintenance of cell polarity regulating cell shape	ISO	J:155856
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0000226	microtubule cytoskeleton organization	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0001764	neuron migration	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0050770	regulation of axonogenesis	ISO	J:164563
Biological Process	GO:0051493	regulation of cytoskeleton organization	ISO	J:155856
Biological Process	GO:1904526	regulation of microtubule binding	ISO	J:155856
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:155856
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000