GO Annotations Graph

• Symbol: S1pr2
• Name: sphingosine-1-phosphate receptor 2
• ID: MGI:99569

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	ISO	J:281765
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	ISO	J:281765
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:155856
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:208445
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	ISO	J:164563
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	IBA	J:265628
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	ISO	J:281765
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:281765
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:73957
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:73957
Biological Process	GO:0046847	filopodium assembly	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:281765
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:281765
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	IMP	J:73957
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:281765
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:281765
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IMP	J:194000
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	ISO	J:164563
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	IMP	J:194000
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	IBA	J:265628