Twist1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Twist1
twist basic helix-loop-helix transcription factor 1
MGI:98872

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:302456
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TAS	J:180494
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:161110
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:165714
Molecular Function	GO:0070888	E-box binding	IDA	J:108218
Molecular Function	GO:0070888	E-box binding	TAS	J:180494
Molecular Function	GO:0070888	E-box binding	IMP	J:203819
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	IDA	J:147973
Molecular Function	GO:0042802	identical protein binding	IPI	J:108218
Molecular Function	GO:0005515	protein binding	IPI	J:190125
Molecular Function	GO:0005515	protein binding	IPI	J:245246
Molecular Function	GO:0005515	protein binding	IPI	J:108218
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:90056
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:108218
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0001221	transcription coregulator binding	IPI	J:147973
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007869
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:133640
Cellular Component	GO:0005634	nucleus	IDA	J:133640
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:165714
Biological Process	GO:0003180	aortic valve morphogenesis	ISO	J:164563
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	IMP	J:138404
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP	J:138404
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:2000793	cell proliferation involved in heart valve development	IMP	J:165714
Biological Process	GO:2000793	cell proliferation involved in heart valve development	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	IMP	J:175157
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0060363	cranial suture morphogenesis	IMP	J:108218
Biological Process	GO:0060363	cranial suture morphogenesis	IMP	J:90056
Biological Process	GO:0060363	cranial suture morphogenesis	IMP	J:79294
Biological Process	GO:0060363	cranial suture morphogenesis	IMP	J:79294
Biological Process	GO:0060363	cranial suture morphogenesis	IMP	J:90056
Biological Process	GO:0032502	developmental process	IBA	J:265628
Biological Process	GO:0060900	embryonic camera-type eye formation	ISO	J:164563
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:44379
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	ISO	J:164563
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:90056
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:90056
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IMP	J:76826
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:44379
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:78407
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:69450
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:90056
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IMP	J:90056
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:138404
Biological Process	GO:0097009	energy homeostasis	IDA	J:147973
Biological Process	GO:0061029	eyelid development in camera-type eye	ISO	J:164563
Biological Process	GO:0035137	hindlimb morphogenesis	IMP	J:60747
Biological Process	GO:0001701	in utero embryonic development	IMP	J:90056
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:124396
Biological Process	GO:0003183	mitral valve morphogenesis	IMP	J:165714
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007517	muscle organ development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:76826
Biological Process	GO:0045596	negative regulation of cell differentiation	IDA	J:46519
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:207820
Biological Process	GO:2000780	negative regulation of double-strand break repair	ISO	J:164563
Biological Process	GO:0035067	negative regulation of histone acetylation	IDA	J:147973
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IGI	J:124396
Biological Process	GO:0044092	negative regulation of molecular function	IDA	J:90056
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IDA	J:90056
Biological Process	GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity	IDA	J:147973
Biological Process	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	IDA	J:147973
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	IDA	J:21111
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	IDA	J:28430
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	IDA	J:46519
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:147973
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:108218
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:28430
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IGI	J:124396
Biological Process	GO:0001843	neural tube closure	IMP	J:24349
Biological Process	GO:0001764	neuron migration	IMP	J:90276
Biological Process	GO:0001503	ossification	IMP	J:90056
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:90056
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:90056
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:2000147	positive regulation of cell motility	IMP	J:175172
Biological Process	GO:2000144	positive regulation of DNA-templated transcription initiation	ISO	J:164563
Biological Process	GO:2000802	positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	IDA	J:165714
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:175172
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:175157
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:165714
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TAS	J:180494
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:165714
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:161110
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:203819
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:203819
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:203819
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0030500	regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0048863	stem cell differentiation	IMP	J:78407
Biological Process	GO:0048863	stem cell differentiation	IMP	J:78407
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:124396

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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