GO Annotations Graph

• Symbol: Tbx1
• Name: T-box 1
• ID: MGI:98493

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:107397
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:207648
Molecular Function	GO:0005515	protein binding	IPI	J:167713
Molecular Function	GO:0005515	protein binding	IPI	J:183479
Molecular Function	GO:0005515	protein binding	IPI	J:162660
Molecular Function	GO:0005515	protein binding	IPI	J:166613
Molecular Function	GO:0042803	protein homodimerization activity	ISS	J:42496
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA	J:107397
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISS	J:42496
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISS	J:42496
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:117856
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Cellular Component	GO:0005634	nucleus	IDA	J:139636
Biological Process	GO:0036305	ameloblast differentiation	IMP	J:166613
Biological Process	GO:0036305	ameloblast differentiation	IMP	J:149254
Biological Process	GO:0036305	ameloblast differentiation	IMP	J:149254
Biological Process	GO:0001525	angiogenesis	IMP	J:76173
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:105259
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:89188
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:105259
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:105259
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:105259
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0035909	aorta morphogenesis	IMP	J:130110
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0048844	artery morphogenesis	IGI	J:213584
Biological Process	GO:0048844	artery morphogenesis	IGI	J:154590
Biological Process	GO:0048844	artery morphogenesis	IGI	J:152319
Biological Process	GO:0048844	artery morphogenesis	IMP	J:70730
Biological Process	GO:0001568	blood vessel development	IGI	J:105259
Biological Process	GO:0001568	blood vessel development	IMP	J:102843
Biological Process	GO:0001568	blood vessel development	IGI	J:105259
Biological Process	GO:0001568	blood vessel development	IGI	J:105259
Biological Process	GO:0001568	blood vessel development	IMP	J:67409
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:67796
Biological Process	GO:0001974	blood vessel remodeling	IGI	J:114854
Biological Process	GO:0001974	blood vessel remodeling	IGI	J:114854
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	TAS	J:169941
Biological Process	GO:0001708	cell fate specification	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IMP	J:127213
Biological Process	GO:0008283	cell population proliferation	IMP	J:127213
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	IMP	J:175333
Biological Process	GO:0071300	cellular response to retinoic acid	IEP	J:139633
Biological Process	GO:0090103	cochlea morphogenesis	IGI	J:175160
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:128008
Biological Process	GO:0060982	coronary artery morphogenesis	TAS	J:169941
Biological Process	GO:0060982	coronary artery morphogenesis	IMP	J:151368
Biological Process	GO:1904888	cranial skeletal system development	IGI	J:146769
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:107397
Biological Process	GO:0042471	ear morphogenesis	IMP	J:91664
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:91664
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	ISO	J:164563
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	ISS	J:42496
Biological Process	GO:0070166	enamel mineralization	IMP	J:149254
Biological Process	GO:0070166	enamel mineralization	IMP	J:149254
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:149254
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:119950
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:166613
Biological Process	GO:0060325	face morphogenesis	IMP	J:163487
Biological Process	GO:0060022	hard palate development	IMP	J:270507
Biological Process	GO:0007507	heart development	ISS	J:42496
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0007507	heart development	IMP	J:167713
Biological Process	GO:0007507	heart development	IMP	J:76173
Biological Process	GO:0007507	heart development	IMP	J:70730
Biological Process	GO:0007507	heart development	IMP	J:107397
Biological Process	GO:0007507	heart development	IMP	J:67796
Biological Process	GO:0007507	heart development	IGI	J:107397
Biological Process	GO:0007507	heart development	IGI	J:105259
Biological Process	GO:0003007	heart morphogenesis	IMP	J:91013
Biological Process	GO:0003007	heart morphogenesis	IMP	J:110620
Biological Process	GO:0003007	heart morphogenesis	IMP	J:91664
Biological Process	GO:0003007	heart morphogenesis	IMP	J:112457
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:109536
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:85072
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:96463
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:89188
Biological Process	GO:0001945	lymph vessel development	IMP	J:159824
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:175160
Biological Process	GO:0010463	mesenchymal cell proliferation	IDA	J:112457
Biological Process	GO:0007498	mesoderm development	IMP	J:70730
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:163487
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:96463
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:109536
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042693	muscle cell fate commitment	IMP	J:139636
Biological Process	GO:0042693	muscle cell fate commitment	IMP	J:139636
Biological Process	GO:0042693	muscle cell fate commitment	IMP	J:139636
Biological Process	GO:0042693	muscle cell fate commitment	IMP	J:139636
Biological Process	GO:0007517	muscle organ development	IMP	J:94411
Biological Process	GO:0007517	muscle organ development	IMP	J:94411
Biological Process	GO:0048644	muscle organ morphogenesis	IGI	J:150130
Biological Process	GO:0060415	muscle tissue morphogenesis	IMP	J:150130
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:169957
Biological Process	GO:2001054	negative regulation of mesenchymal cell apoptotic process	IGI	J:175160
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:160266
Biological Process	GO:0001755	neural crest cell migration	IMP	J:96463
Biological Process	GO:0001755	neural crest cell migration	IMP	J:96463
Biological Process	GO:0001755	neural crest cell migration	IMP	J:163487
Biological Process	GO:0048665	neuron fate specification	IGI	J:90585
Biological Process	GO:0048665	neuron fate specification	IMP	J:89188
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:149254
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:166613
Biological Process	GO:0071600	otic vesicle morphogenesis	IMP	J:119950
Biological Process	GO:0042473	outer ear morphogenesis	IMP	J:109536
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:151368
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:130110
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:175333
Biological Process	GO:0060017	parathyroid gland development	ISS	J:42496
Biological Process	GO:0060017	parathyroid gland development	ISO	J:164563
Biological Process	GO:0007389	pattern specification process	IGI	J:105259
Biological Process	GO:0007389	pattern specification process	IMP	J:94411
Biological Process	GO:0007389	pattern specification process	IMP	J:96463
Biological Process	GO:0007389	pattern specification process	IGI	J:105259
Biological Process	GO:0060037	pharyngeal system development	ISS	J:42496
Biological Process	GO:0060037	pharyngeal system development	IMP	J:167713
Biological Process	GO:0060037	pharyngeal system development	ISO	J:164563
Biological Process	GO:0060037	pharyngeal system development	IMP	J:127213
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:127213
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:91013
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:110101
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:101739
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:98074
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:175160
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:149254
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:166613
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:119950
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:128008
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:149254
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:175333
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:175160
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:175333
Biological Process	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	IDA	J:169957
Biological Process	GO:2001037	positive regulation of tongue muscle cell differentiation	IMP	J:139633
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:107397
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:167713
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:160266
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162660
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:107397
Biological Process	GO:2000027	regulation of animal organ morphogenesis	IMP	J:117856
Biological Process	GO:2000027	regulation of animal organ morphogenesis	IMP	J:149463
Biological Process	GO:2000027	regulation of animal organ morphogenesis	IGI	J:149463
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:166613
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IMP	J:139633
Biological Process	GO:0048752	semicircular canal morphogenesis	IGI	J:154590
Biological Process	GO:0007605	sensory perception of sound	IMP	J:91664
Biological Process	GO:0007605	sensory perception of sound	IMP	J:109536
Biological Process	GO:0035176	social behavior	IMP	J:110101
Biological Process	GO:0060023	soft palate development	ISS	J:42496
Biological Process	GO:0060023	soft palate development	ISO	J:164563
Biological Process	GO:0048538	thymus development	ISS	J:42496
Biological Process	GO:0048538	thymus development	ISO	J:164563
Biological Process	GO:0048538	thymus development	IMP	J:130110
Biological Process	GO:0030878	thyroid gland development	IMP	J:117856
Biological Process	GO:0030878	thyroid gland development	IGI	J:149463
Biological Process	GO:0030878	thyroid gland development	IMP	J:149463
Biological Process	GO:0030878	thyroid gland development	IMP	J:91664
Biological Process	GO:0043587	tongue morphogenesis	IMP	J:139633
Biological Process	GO:0021644	vagus nerve morphogenesis	IMP	J:171024