GO Annotations Graph

• Symbol: Scn5a
• Name: sodium channel, voltage-gated, type V, alpha
• ID: MGI:98251

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030506	ankyrin binding	ISO	J:164563
Molecular Function	GO:0030506	ankyrin binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:155856
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:164563
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:187546
Molecular Function	GO:0005515	protein binding	IPI	J:221558
Molecular Function	GO:0005515	protein binding	IPI	J:184959
Molecular Function	GO:0005515	protein binding	IPI	J:187546
Molecular Function	GO:0005515	protein binding	IPI	J:184957
Molecular Function	GO:0005515	protein binding	IPI	J:255706
Molecular Function	GO:0005515	protein binding	IPI	J:93341
Molecular Function	GO:0005515	protein binding	IPI	J:93341
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:198910
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:303083
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IDA	J:303083
Molecular Function	GO:0086060	voltage-gated sodium channel activity involved in AV node cell action potential	ISO	J:164563
Molecular Function	GO:0086061	voltage-gated sodium channel activity involved in bundle of His cell action potential	ISO	J:164563
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO	J:155856
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO	J:164563
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IBA	J:265628
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IMP	J:76331
Molecular Function	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential	ISO	J:164563
Molecular Function	GO:0086063	voltage-gated sodium channel activity involved in SA node cell action potential	ISO	J:164563
Molecular Function	GO:0086063	voltage-gated sodium channel activity involved in SA node cell action potential	IMP	J:151611
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:127606
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0014704	intercalated disc	ISO	J:164563
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0014704	intercalated disc	IDA	J:127606
Cellular Component	GO:0014704	intercalated disc	IDA	J:187546
Cellular Component	GO:0014704	intercalated disc	IDA	J:184959
Cellular Component	GO:0014704	intercalated disc	IDA	J:165334
Cellular Component	GO:0014704	intercalated disc	IDA	J:93341
Cellular Component	GO:0014704	intercalated disc	IDA	J:161910
Cellular Component	GO:0014704	intercalated disc	IDA	J:239053
Cellular Component	GO:0014704	intercalated disc	IDA	J:109097
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:187546
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:109097
Cellular Component	GO:0005886	plasma membrane	IDA	J:303083
Cellular Component	GO:0042383	sarcolemma	ISO	J:164563
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	IDA	J:161910
Cellular Component	GO:0030315	T-tubule	IDA	J:109097
Cellular Component	GO:0001518	voltage-gated sodium channel complex	ISO	J:164563
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IC	J:108205
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086016	AV node cell action potential	ISO	J:164563
Biological Process	GO:0086067	AV node cell to bundle of His cell communication	ISO	J:164563
Biological Process	GO:0086043	bundle of His cell action potential	ISO	J:164563
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0003231	cardiac ventricle development	IMP	J:76331
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0051899	membrane depolarization	ISO	J:164563
Biological Process	GO:0086010	membrane depolarization during action potential	ISO	J:164563
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	ISO	J:164563
Biological Process	GO:0086048	membrane depolarization during bundle of His cell action potential	ISO	J:164563
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	ISO	J:155856
Biological Process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	ISO	J:164563
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0045760	positive regulation of action potential	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0010765	positive regulation of sodium ion transport	ISO	J:164563
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	ISO	J:164563
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	IBA	J:265628
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	ISO	J:164563
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:164563
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IMP	J:116845
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0002027	regulation of heart rate	IBA	J:265628
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:151611
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:116845
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:76331
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:109689
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:1902305	regulation of sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	ISO	J:164563
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	ISO	J:164563
Biological Process	GO:0014894	response to denervation involved in regulation of muscle adaptation	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	IMP	J:169955
Biological Process	GO:0086015	SA node cell action potential	ISO	J:164563
Biological Process	GO:0098719	sodium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:208111
Biological Process	GO:0035725	sodium ion transmembrane transport	IDA	J:303083
Biological Process	GO:0006814	sodium ion transport	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ISO	J:164563