GO Annotations Graph

• Symbol: Pparg
• Name: peroxisome proliferator activated receptor gamma
• ID: MGI:97747

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0050544	arachidonic acid binding	IDA	J:135483
Molecular Function	GO:0003682	chromatin binding	IDA	J:167907
Molecular Function	GO:0003682	chromatin binding	IDA	J:204719
Molecular Function	GO:0003682	chromatin binding	IDA	J:197105
Molecular Function	GO:0003682	chromatin binding	IDA	J:198125
Molecular Function	GO:0003682	chromatin binding	IDA	J:142665
Molecular Function	GO:0003682	chromatin binding	IDA	J:197105
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:19422
Molecular Function	GO:0003677	DNA binding	IDA	J:76817
Molecular Function	GO:0050692	DNA binding domain binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:197105
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:167907
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:76817
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:144377
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0050693	LBD domain binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:189993
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:78315
Molecular Function	GO:0030374	nuclear receptor coactivator activity	IDA	J:167907
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0042277	peptide binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:262213
Molecular Function	GO:0005515	protein binding	IPI	J:273515
Molecular Function	GO:0005515	protein binding	IPI	J:138823
Molecular Function	GO:0005515	protein binding	IPI	J:187882
Molecular Function	GO:0005515	protein binding	IPI	J:161288
Molecular Function	GO:0005515	protein binding	IPI	J:255965
Molecular Function	GO:0005515	protein binding	IPI	J:91106
Molecular Function	GO:0005515	protein binding	IPI	J:209483
Molecular Function	GO:0005515	protein binding	IPI	J:167907
Molecular Function	GO:0005515	protein binding	IPI	J:101497
Molecular Function	GO:0005515	protein binding	IPI	J:43438
Molecular Function	GO:0005515	protein binding	IPI	J:261911
Molecular Function	GO:0005515	protein binding	IPI	J:100164
Molecular Function	GO:0005515	protein binding	IPI	J:96189
Molecular Function	GO:0005515	protein binding	IPI	J:184223
Molecular Function	GO:0005515	protein binding	IPI	J:251809
Molecular Function	GO:0005515	protein binding	IPI	J:125396
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:96189
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:91368
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA	J:272999
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA	J:272999
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:91833
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0097677	STAT family protein binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:101497
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:167907
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:164563
Molecular Function	GO:0050699	WW domain binding	ISO	J:184223
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:161288
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:90902
Cellular Component	GO:0005829	cytosol	IDA	J:78315
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-442475
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-442515
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-4717507
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-556760
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017440
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:161288
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:90902
Cellular Component	GO:0005634	nucleus	IDA	J:78315
Cellular Component	GO:0005634	nucleus	IDA	J:175461
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0050873	brown fat cell differentiation	IDA	J:137608
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0045165	cell fate commitment	IMP	J:213144
Biological Process	GO:0045165	cell fate commitment	IGI	J:95883
Biological Process	GO:0048469	cell maturation	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IMP	J:79682
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:234039
Biological Process	GO:0071285	cellular response to lithium ion	IDA	J:99298
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:78619
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IMP	J:191553
Biological Process	GO:0106106	cold-induced thermogenesis	IMP	J:276211
Biological Process	GO:0002024	diet induced thermogenesis	IMP	J:213144
Biological Process	GO:0030855	epithelial cell differentiation	IGI	J:95883
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:79682
Biological Process	GO:0045444	fat cell differentiation	IMP	J:142665
Biological Process	GO:0045444	fat cell differentiation	IDA	J:81172
Biological Process	GO:0045444	fat cell differentiation	IDA	J:125420
Biological Process	GO:0045444	fat cell differentiation	IDA	J:91833
Biological Process	GO:0045444	fat cell differentiation	IDA	J:97016
Biological Process	GO:0045444	fat cell differentiation	IPI	J:125396
Biological Process	GO:0045444	fat cell differentiation	IGI	J:142665
Biological Process	GO:0045444	fat cell differentiation	IMP	J:184223
Biological Process	GO:0045444	fat cell differentiation	IDA	J:76817
Biological Process	GO:0045444	fat cell differentiation	IDA	J:92922
Biological Process	GO:0045444	fat cell differentiation	IGI	J:100164
Biological Process	GO:0019395	fatty acid oxidation	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0009755	hormone-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	TAS	J:78315
Biological Process	GO:0042953	lipoprotein transport	ISO	J:164563
Biological Process	GO:0015909	long-chain fatty acid transport	IMP	J:129630
Biological Process	GO:0015909	long-chain fatty acid transport	IMP	J:129630
Biological Process	GO:0010742	macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0030224	monocyte differentiation	ISO	J:164563
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0002674	negative regulation of acute inflammatory response	ISO	J:155856
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	IMP	J:196126
Biological Process	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0010887	negative regulation of cholesterol storage	ISO	J:164563
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:1904597	negative regulation of connective tissue replacement involved in inflammatory response wound healing	ISO	J:155856
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:137408
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:101497
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:96189
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:96189
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:79682
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:253285
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:191553
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:191553
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:253285
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:253285
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0010888	negative regulation of lipid storage	ISO	J:155856
Biological Process	GO:0010888	negative regulation of lipid storage	IMP	J:261538
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:1903979	negative regulation of microglial cell activation	IGI	J:268006
Biological Process	GO:1902894	negative regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0060965	negative regulation of miRNA-mediated gene silencing	ISO	J:164563
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IGI	J:268006
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:2000230	negative regulation of pancreatic stellate cell proliferation	ISO	J:155856
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0090278	negative regulation of peptide hormone secretion	IMP	J:196126
Biological Process	GO:1904893	negative regulation of receptor signaling pathway via STAT	ISO	J:164563
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	ISO	J:164563
Biological Process	GO:2000272	negative regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0060392	negative regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	IMP	J:191553
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	IDA	J:191553
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IGI	J:136168
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IMP	J:191553
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IDA	J:191553
Biological Process	GO:0051974	negative regulation of telomerase activity	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:101497
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:19422
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060336	negative regulation of type II interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway	NAS	J:319988
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway	IPI	J:125396
Biological Process	GO:0001890	placenta development	IMP	J:129630
Biological Process	GO:0001890	placenta development	IMP	J:129630
Biological Process	GO:0070165	positive regulation of adiponectin secretion	ISO	J:155856
Biological Process	GO:1904179	positive regulation of adipose tissue development	IMP	J:302459
Biological Process	GO:1904179	positive regulation of adipose tissue development	NAS	J:319988
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:167907
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:88279
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:98564
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:148702
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IDA	J:167907
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:289252
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:136168
Biological Process	GO:1905599	positive regulation of low-density lipoprotein receptor activity	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IGI	J:289252
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:155856
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	IGI	J:289252
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:101497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:189993
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:198125
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:198125
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:100164
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:230753
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:76817
Biological Process	GO:0061411	positive regulation of transcription from RNA polymerase II promoter in response to cold	IMP	J:276211
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:164563
Biological Process	GO:1900076	regulation of cellular response to insulin stimulus	NAS	J:319988
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:144377
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:144377
Biological Process	GO:0045598	regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:213144
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:155856
Biological Process	GO:0019216	regulation of lipid metabolic process	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:148702
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:234039
Biological Process	GO:0002021	response to dietary excess	IDA	J:213144
Biological Process	GO:0032094	response to food	IDA	J:144377
Biological Process	GO:0009416	response to light stimulus	IDA	J:144377
Biological Process	GO:0033993	response to lipid	IDA	J:135483
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IDA	J:189993
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0050872	white fat cell differentiation	IDA	J:137608
Biological Process	GO:0050872	white fat cell differentiation	IGI	J:130039
Biological Process	GO:0002246	wound healing involved in inflammatory response	IDA	J:191553