GO Annotations Graph

• Symbol: Plk1
• Name: polo like kinase 1
• ID: MGI:97621

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010997	anaphase-promoting complex binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:320154
Molecular Function	GO:0005515	protein binding	IPI	J:183245
Molecular Function	GO:0005515	protein binding	IPI	J:239231
Molecular Function	GO:0005515	protein binding	IPI	J:216866
Molecular Function	GO:0004672	protein kinase activity	IDA	J:281562
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:199766
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:183245
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:239231
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:239231
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0034451	centriolar satellite	IDA	J:239231
Cellular Component	GO:0005814	centriole	IDA	J:239231
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0000785	chromatin	IDA	J:199766
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:240155
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:240155
Cellular Component	GO:0000779	condensed chromosome, centromeric region	IDA	J:199766
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0000776	kinetochore	ISO	J:164563
Cellular Component	GO:0000776	kinetochore	IBA	J:265628
Cellular Component	GO:0000776	kinetochore	IDA	J:216866
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:191250
Cellular Component	GO:0097431	mitotic spindle pole	IDA	J:240155
Cellular Component	GO:0097431	mitotic spindle pole	IDA	J:240155
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0000940	outer kinetochore	ISO	J:164563
Cellular Component	GO:0005819	spindle	ISO	J:164563
Cellular Component	GO:0005876	spindle microtubule	ISO	J:164563
Cellular Component	GO:0051233	spindle midzone	ISO	J:155856
Cellular Component	GO:0051233	spindle midzone	ISO	J:164563
Cellular Component	GO:0000922	spindle pole	ISO	J:155856
Cellular Component	GO:0000922	spindle pole	ISO	J:164563
Cellular Component	GO:0000922	spindle pole	IBA	J:265628
Cellular Component	GO:0000922	spindle pole	ISO	J:204810
Cellular Component	GO:0000795	synaptonemal complex	IDA	J:199766
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0007098	centrosome cycle	ISO	J:164563
Biological Process	GO:0000132	establishment of mitotic spindle orientation	ISO	J:164563
Biological Process	GO:0045184	establishment of protein localization	ISO	J:204810
Biological Process	GO:0016321	female meiosis chromosome segregation	IMP	J:216866
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045143	homologous chromosome segregation	IMP	J:216866
Biological Process	GO:0001578	microtubule bundle formation	ISO	J:164563
Biological Process	GO:0000278	mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000281	mitotic cytokinesis	ISO	J:164563
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0000070	mitotic sister chromatid segregation	ISO	J:164563
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	ISO	J:164563
Biological Process	GO:0007052	mitotic spindle organization	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051081	nuclear membrane disassembly	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:239231
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:239231
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0040038	polar body extrusion after meiotic divisions	ISO	J:155856
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:164563
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity	ISO	J:164563
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0090435	protein localization to nuclear envelope	ISO	J:164563
Biological Process	GO:0033365	protein localization to organelle	IDA	J:239231
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IMP	J:281562
Biological Process	GO:0006468	protein phosphorylation	IMP	J:199766
Biological Process	GO:0006468	protein phosphorylation	ISO	J:73065
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0032465	regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition	ISO	J:164563
Biological Process	GO:1901673	regulation of mitotic spindle assembly	ISO	J:164563
Biological Process	GO:0043393	regulation of protein binding	ISO	J:164563
Biological Process	GO:0043393	regulation of protein binding	IMP	J:239231
Biological Process	GO:1904776	regulation of protein localization to cell cortex	ISO	J:164563
Biological Process	GO:0070194	synaptonemal complex disassembly	IMP	J:199766