Pdgfa GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pdgfa
platelet derived growth factor, alpha
MGI:97527

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005518	collagen binding	ISO	J:73065
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:162978
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005902	microvillus	IDA	J:78275
Cellular Component	GO:1990265	platelet-derived growth factor complex	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IDA	J:78781
Biological Process	GO:0001525	angiogenesis	IDA	J:78275
Biological Process	GO:0009887	animal organ morphogenesis	IGI	J:93954
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:89838
Biological Process	GO:0060348	bone development	IGI	J:205009
Biological Process	GO:0008283	cell population proliferation	IMP	J:54912
Biological Process	GO:0030031	cell projection assembly	IDA	J:78781
Biological Process	GO:0048565	digestive tract development	IMP	J:63212
Biological Process	GO:0048565	digestive tract development	IGI	J:205009
Biological Process	GO:1990401	embryonic lung development	IMP	J:43767
Biological Process	GO:0001942	hair follicle development	IMP	J:54912
Biological Process	GO:0048286	lung alveolus development	IMP	J:43767
Biological Process	GO:0048286	lung alveolus development	IMP	J:205009
Biological Process	GO:0048286	lung alveolus development	IMP	J:108040
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	ISO	J:164563
Biological Process	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0010544	negative regulation of platelet activation	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	NAS	J:320129
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	NAS	J:320129
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:54912
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:54912
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:54912
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:54912
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:54912
Biological Process	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:164563
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	IBA	J:265628
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	IMP	J:140258
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IDA	J:77668
Biological Process	GO:0014910	regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0009611	response to wounding	ISO	J:164563
Biological Process	GO:0043588	skin development	IMP	J:54912

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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