GO Annotations Graph

• Symbol: Ntrk2
• Name: neurotrophic tyrosine kinase, receptor, type 2
• ID: MGI:97384

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	IDA	J:41382
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	ISO	J:155856
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	IBA	J:265628
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	ISO	J:164563
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	ISO	J:155856
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	IDA	J:180470
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0043121	neurotrophin binding	IDA	J:41382
Molecular Function	GO:0043121	neurotrophin binding	ISO	J:155856
Molecular Function	GO:0043121	neurotrophin binding	ISO	J:164563
Molecular Function	GO:0005030	neurotrophin receptor activity	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:194528
Molecular Function	GO:0005515	protein binding	IPI	J:166236
Molecular Function	GO:0005515	protein binding	IPI	J:208015
Molecular Function	GO:0005515	protein binding	IPI	J:184958
Molecular Function	GO:0005515	protein binding	IPI	J:170255
Molecular Function	GO:0005515	protein binding	IPI	J:171253
Molecular Function	GO:0005515	protein binding	IPI	J:239200
Molecular Function	GO:0005515	protein binding	IPI	J:180470
Molecular Function	GO:0005515	protein binding	IPI	J:130626
Molecular Function	GO:0005515	protein binding	IPI	J:72304
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0005515	protein binding	IPI	J:111724
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:74053
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0005769	early endosome	IDA	J:239200
Cellular Component	GO:0005768	endosome	IDA	J:201826
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9031076
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9031553
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9032771
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9025041
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9025059
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9026445
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9030427
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9030433
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9030473
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9033304
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9033333
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9033341
Cellular Component	GO:0005886	plasma membrane	IDA	J:83933
Cellular Component	GO:0005886	plasma membrane	IDA	J:83641
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:96801
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IDA	J:207532
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:224118
Cellular Component	GO:0043195	terminal bouton	IDA	J:111724
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	IDA	J:180470
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	IMP	J:180482
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:219199
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	IBA	J:265628
Biological Process	GO:0021954	central nervous system neuron development	IMP	J:56847
Biological Process	GO:0021987	cerebral cortex development	IMP	J:132562
Biological Process	GO:0007623	circadian rhythm	IEP	J:199564
Biological Process	GO:0007631	feeding behavior	IMP	J:84073
Biological Process	GO:0014047	glutamate secretion	IPI	J:111724
Biological Process	GO:0007612	learning	IMP	J:58229
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:130626
Biological Process	GO:0042490	mechanoreceptor differentiation	IMP	J:93853
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0022011	myelination in peripheral nervous system	IGI	J:162328
Biological Process	GO:0022011	myelination in peripheral nervous system	IGI	J:162328
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:2000811	negative regulation of anoikis	IDA	J:180478
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0030182	neuron differentiation	IMP	J:132562
Biological Process	GO:0001764	neuron migration	IMP	J:132562
Biological Process	GO:0019227	neuronal action potential propagation	IGI	J:162328
Biological Process	GO:0019227	neuronal action potential propagation	IGI	J:162328
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:132562
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:204740
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:204740
Biological Process	GO:0048935	peripheral nervous system neuron development	IMP	J:56847
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0050772	positive regulation of axonogenesis	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:130626
Biological Process	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	ISO	J:73065
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	IDA	J:180470
Biological Process	GO:0010976	positive regulation of neuron projection development	IBA	J:265628
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:204740
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0051965	positive regulation of synapse assembly	IDA	J:211830
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0050773	regulation of dendrite development	ISO	J:155856
Biological Process	GO:0043087	regulation of GTPase activity	IDA	J:180470
Biological Process	GO:0043408	regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0019222	regulation of metabolic process	IMP	J:84073
Biological Process	GO:0046928	regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0051896	regulation of protein kinase B signaling	IMP	J:132562
Biological Process	GO:0051896	regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0060041	retina development in camera-type eye	IMP	J:219199
Biological Process	GO:0046548	retinal rod cell development	IMP	J:89227
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA	J:224118
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	IMP	J:224118
Biological Process	GO:0099551	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	IMP	J:224118
Biological Process	GO:0099551	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	IMP	J:102417
Biological Process	GO:0001570	vasculogenesis	IMP	J:102417
Biological Process	GO:0001570	vasculogenesis	IMP	J:102417