GO Annotations Graph

• Symbol: Nkx2-3
• Name: NK2 homeobox 3
• ID: MGI:97348

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0030183	B cell differentiation	IMP	J:82729
Biological Process	GO:0043367	CD4-positive, alpha-beta T cell differentiation	IMP	J:64018
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0048565	digestive tract development	IMP	J:54198
Biological Process	GO:0048565	digestive tract development	IMP	J:64018
Biological Process	GO:0022612	gland morphogenesis	IMP	J:64018
Biological Process	GO:0006955	immune response	IMP	J:82729
Biological Process	GO:0001776	leukocyte homeostasis	IMP	J:64018
Biological Process	GO:0050900	leukocyte migration	IMP	J:64018
Biological Process	GO:0050900	leukocyte migration	IMP	J:62129
Biological Process	GO:0048535	lymph node development	IMP	J:64018
Biological Process	GO:0048535	lymph node development	IMP	J:62129
Biological Process	GO:0030225	macrophage differentiation	IMP	J:64018
Biological Process	GO:0048537	mucosa-associated lymphoid tissue development	IMP	J:64018
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:80726
Biological Process	GO:0048541	Peyer's patch development	IMP	J:62129
Biological Process	GO:0002317	plasma cell differentiation	IMP	J:64018
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:62129
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:64018
Biological Process	GO:0009791	post-embryonic development	IMP	J:64018
Biological Process	GO:0048621	post-embryonic digestive tract morphogenesis	IMP	J:64018
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:54198
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048536	spleen development	IMP	J:64018
Biological Process	GO:0048536	spleen development	IMP	J:62129
Biological Process	GO:0048536	spleen development	IMP	J:54198
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:64018
Biological Process	GO:0006641	triglyceride metabolic process	IMP	J:64018