GO Annotations Graph

• Symbol: Nfkb1
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
• ID: MGI:97312

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042805	actinin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:214867
Molecular Function	GO:0003682	chromatin binding	IDA	J:214867
Molecular Function	GO:0003682	chromatin binding	IDA	J:204792
Molecular Function	GO:0003682	chromatin binding	IDA	J:163557
Molecular Function	GO:0003682	chromatin binding	IDA	J:204792
Molecular Function	GO:0003677	DNA binding	ISO	J:150450
Molecular Function	GO:0003677	DNA binding	IDA	J:56156
Molecular Function	GO:0003677	DNA binding	IDA	J:82431
Molecular Function	GO:0003677	DNA binding	IDA	J:152781
Molecular Function	GO:0003677	DNA binding	IDA	J:202853
Molecular Function	GO:0003677	DNA binding	IDA	J:76135
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:73065
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:91804
Molecular Function	GO:0005515	protein binding	IPI	J:230622
Molecular Function	GO:0005515	protein binding	IPI	J:197511
Molecular Function	GO:0005515	protein binding	IPI	J:163302
Molecular Function	GO:0005515	protein binding	IPI	J:190685
Molecular Function	GO:0005515	protein binding	IPI	J:200508
Molecular Function	GO:0005515	protein binding	IPI	J:127192
Molecular Function	GO:0005515	protein binding	IPI	J:160776
Molecular Function	GO:0005515	protein binding	IPI	J:247479
Molecular Function	GO:0005515	protein binding	IPI	J:175173
Molecular Function	GO:0005515	protein binding	IPI	J:113974
Molecular Function	GO:0005515	protein binding	IPI	J:245354
Molecular Function	GO:0005515	protein binding	IPI	J:91804
Molecular Function	GO:0005515	protein binding	IPI	J:161367
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:107516
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:97945
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:100877
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:21626
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:148250
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	IDA	J:97246
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:157867
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:75807
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0071159	NF-kappaB complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:287108
Cellular Component	GO:0005634	nucleus	IDA	J:96628
Cellular Component	GO:0005634	nucleus	IDA	J:148250
Cellular Component	GO:0005634	nucleus	IDA	J:85495
Cellular Component	GO:0005634	nucleus	IDA	J:91804
Cellular Component	GO:0005634	nucleus	IDA	J:75807
Cellular Component	GO:0005634	nucleus	IDA	J:157867
Cellular Component	GO:0005634	nucleus	IDA	J:99289
Cellular Component	GO:0005634	nucleus	IDA	J:152781
Cellular Component	GO:0005634	nucleus	IDA	J:56156
Cellular Component	GO:0005634	nucleus	IDA	J:177648
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:121485
Biological Process	GO:1904385	cellular response to angiotensin	ISO	J:164563
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	ISO	J:155856
Biological Process	GO:0071322	cellular response to carbohydrate stimulus	ISO	J:155856
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:150450
Biological Process	GO:1904630	cellular response to diterpene	ISO	J:155856
Biological Process	GO:0071359	cellular response to dsRNA	IMP	J:214872
Biological Process	GO:1904632	cellular response to glucoside	ISO	J:155856
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:155856
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:277730
Biological Process	GO:0071354	cellular response to interleukin-6	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:293611
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:205449
Biological Process	GO:0071316	cellular response to nicotine	ISO	J:164563
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:150450
Biological Process	GO:1901653	cellular response to peptide	ISO	J:155856
Biological Process	GO:0033554	cellular response to stress	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA	J:211147
Biological Process	GO:0098586	cellular response to virus	IMP	J:141299
Biological Process	GO:0032602	chemokine production	IMP	J:287108
Biological Process	GO:0001816	cytokine production	IMP	J:287108
Biological Process	GO:0010467	gene expression	IMP	J:290078
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	IMP	J:141299
Biological Process	GO:0048535	lymph node development	TAS	J:60454
Biological Process	GO:0060056	mammary gland involution	IDA	J:204792
Biological Process	GO:0000165	MAPK cascade	IMP	J:141299
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	ISO	J:164563
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:137408
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:86244
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:135247
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IDA	J:86244
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0038061	NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0038061	NIK/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:2000630	positive regulation of miRNA metabolic process	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:155856
Biological Process	GO:2000637	positive regulation of miRNA-mediated gene silencing	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:141299
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:266673
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155827
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:107516
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:96628
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	IMP	J:129237
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034097	response to cytokine	IBA	J:265628
Biological Process	GO:0035994	response to muscle stretch	IDA	J:163557
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247