GO Annotations Graph

• Symbol: Mapt
• Name: microtubule-associated protein tau
• ID: MGI:97180

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:237682
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	IPI	J:257316
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:257324
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0071813	lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0008017	microtubule binding	ISO	J:155856
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0008017	microtubule binding	IBA	J:265628
Molecular Function	GO:0008017	microtubule binding	IDA	J:131406
Molecular Function	GO:0099609	microtubule lateral binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:201934
Molecular Function	GO:0005515	protein binding	IPI	J:201933
Molecular Function	GO:0005515	protein binding	IPI	J:143074
Molecular Function	GO:0005515	protein binding	IPI	J:137305
Molecular Function	GO:0005515	protein binding	IPI	J:142163
Molecular Function	GO:0005515	protein binding	IPI	J:201575
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IPI	J:183209
Molecular Function	GO:0019901	protein kinase binding	IPI	J:74532
Molecular Function	GO:0019901	protein kinase binding	IPI	J:128996
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0015631	tubulin binding	IEA	J:72247
Cellular Component	GO:0030673	axolemma	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:98063
Cellular Component	GO:0030424	axon	IDA	J:17926
Cellular Component	GO:0030424	axon	IDA	J:228724
Cellular Component	GO:0030424	axon	IDA	J:101575
Cellular Component	GO:0030424	axon	IDA	J:17926
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0005930	axoneme	IDA	J:142506
Cellular Component	GO:0044297	cell body	IDA	J:74532
Cellular Component	GO:0044297	cell body	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:160378
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:237682
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0097386	glial cell projection	IDA	J:74532
Cellular Component	GO:0030426	growth cone	ISO	J:164563
Cellular Component	GO:0044304	main axon	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	IDA	J:74532
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:155856
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:101575
Cellular Component	GO:0097418	neurofibrillary tangle	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0034399	nuclear periphery	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:237682
Cellular Component	GO:0005634	nucleus	IDA	J:160378
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0036477	somatodendritic compartment	ISO	J:164563
Cellular Component	GO:0045298	tubulin complex	ISO	J:164563
Biological Process	GO:0007628	adult walking behavior	IGI	J:145003
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0008088	axo-dendritic transport	IGI	J:164887
Biological Process	GO:0048675	axon extension	IMP	J:105224
Biological Process	GO:0048675	axon extension	IMP	J:116415
Biological Process	GO:0048675	axon extension	IMP	J:160378
Biological Process	GO:0007409	axonogenesis	IGI	J:105224
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IMP	J:237682
Biological Process	GO:0048312	intracellular distribution of mitochondria	ISO	J:164563
Biological Process	GO:0046907	intracellular transport	IMP	J:116415
Biological Process	GO:0046907	intracellular transport	IMP	J:116415
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	ISO	J:155856
Biological Process	GO:0007611	learning or memory	ISO	J:164563
Biological Process	GO:0007613	memory	ISO	J:164563
Biological Process	GO:0000226	microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0000226	microtubule cytoskeleton organization	IBA	J:265628
Biological Process	GO:0000226	microtubule cytoskeleton organization	IMP	J:19030
Biological Process	GO:0046785	microtubule polymerization	ISO	J:164563
Biological Process	GO:0047497	mitochondrion transport along microtubule	IMP	J:116415
Biological Process	GO:0051028	mRNA transport	ISO	J:155856
Biological Process	GO:1903748	negative regulation of establishment of protein localization to mitochondrion	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0032387	negative regulation of intracellular transport	IMP	J:116415
Biological Process	GO:0033673	negative regulation of kinase activity	ISO	J:164563
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:0010917	negative regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:1904428	negative regulation of tubulin deacetylation	IGI	J:257316
Biological Process	GO:1904428	negative regulation of tubulin deacetylation	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IMP	J:153129
Biological Process	GO:0031175	neuron projection development	IBA	J:265628
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:164563
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	ISO	J:155856
Biological Process	GO:0031116	positive regulation of microtubule polymerization	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:1903829	positive regulation of protein localization	ISO	J:164563
Biological Process	GO:1902474	positive regulation of protein localization to synapse	ISO	J:164563
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0051258	protein polymerization	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	ISO	J:73065
Biological Process	GO:0050848	regulation of calcium-mediated signaling	ISO	J:164563
Biological Process	GO:1900034	regulation of cellular response to heat	IMP	J:237682
Biological Process	GO:1900034	regulation of cellular response to heat	ISO	J:164563
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0031110	regulation of microtubule polymerization or depolymerization	ISO	J:164563
Biological Process	GO:0060632	regulation of microtubule-based movement	IDA	J:131406
Biological Process	GO:0010288	response to lead ion	ISO	J:155856
Biological Process	GO:0007584	response to nutrient	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0097435	supramolecular fiber organization	ISO	J:164563
Biological Process	GO:0007416	synapse assembly	ISO	J:164563
Biological Process	GO:0050808	synapse organization	ISO	J:164563