GO Annotations Graph

• Symbol: Jak1
• Name: Janus kinase 1
• ID: MGI:96628

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	ISO	J:155856
Molecular Function	GO:0005126	cytokine receptor binding	IBA	J:265628
Molecular Function	GO:0005131	growth hormone receptor binding	ISO	J:155856
Molecular Function	GO:0005131	growth hormone receptor binding	IPI	J:156077
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:84709
Molecular Function	GO:0005515	protein binding	IPI	J:99220
Molecular Function	GO:0005515	protein binding	IPI	J:99220
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9674908
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9674921
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:235355
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:235355
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:235355
Molecular Function	GO:0140537	transcription regulator activator activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295758
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295764
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295768
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8950409
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983294
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983313
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983356
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007126
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007137
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009867
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674900
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674921
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676072
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705471
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707972
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707979
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1067645
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0036016	cellular response to interleukin-3	IDA	J:15255
Biological Process	GO:0098761	cellular response to interleukin-7	IDA	J:260356
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:19201
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	IDA	J:19201
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:19201
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:1904894	positive regulation of receptor signaling pathway via STAT	IMP	J:235355
Biological Process	GO:1904894	positive regulation of receptor signaling pathway via STAT	IMP	J:235355
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0150105	protein localization to cell-cell junction	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0046677	response to antibiotic	ISO	J:107465
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IMP	J:235355
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IMP	J:235355
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IMP	J:235355