GO Annotations Graph

• Symbol: Insr
• Name: insulin receptor
• ID: MGI:96575

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043423	3-phosphoinositide-dependent protein kinase binding	ISO	J:155856
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043559	insulin binding	ISO	J:164563
Molecular Function	GO:0043559	insulin binding	ISO	J:155856
Molecular Function	GO:0005009	insulin receptor activity	ISO	J:155856
Molecular Function	GO:0005009	insulin receptor activity	ISO	J:164563
Molecular Function	GO:0005009	insulin receptor activity	IBA	J:265628
Molecular Function	GO:0005009	insulin receptor activity	IDA	J:326513
Molecular Function	GO:0005009	insulin receptor activity	IDA	J:32474
Molecular Function	GO:0005009	insulin receptor activity	IDA	J:204097
Molecular Function	GO:0005009	insulin receptor activity	IDA	J:204097
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:155856
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:164563
Molecular Function	GO:0043560	insulin receptor substrate binding	IBA	J:265628
Molecular Function	GO:0031994	insulin-like growth factor I binding	ISO	J:164563
Molecular Function	GO:0031995	insulin-like growth factor II binding	ISO	J:164563
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0031405	lipoic acid binding	ISO	J:155856
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:143610
Molecular Function	GO:0140677	molecular function activator activity	IGI	J:38502
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:4645
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:4645
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:204994
Molecular Function	GO:0005515	protein binding	IPI	J:194550
Molecular Function	GO:0005515	protein binding	IPI	J:277932
Molecular Function	GO:0005515	protein binding	IPI	J:200357
Molecular Function	GO:0005515	protein binding	IPI	J:149197
Molecular Function	GO:0005515	protein binding	IPI	J:237133
Molecular Function	GO:0005515	protein binding	IPI	J:46223
Molecular Function	GO:0005515	protein binding	IPI	J:282620
Molecular Function	GO:0005515	protein binding	IPI	J:91027
Molecular Function	GO:0005515	protein binding	IPI	J:107908
Molecular Function	GO:0005515	protein binding	IPI	J:107908
Molecular Function	GO:0005515	protein binding	IPI	J:54187
Molecular Function	GO:0005515	protein binding	IPI	J:186913
Molecular Function	GO:0005515	protein binding	IPI	J:86675
Molecular Function	GO:0005515	protein binding	IPI	J:91027
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IDA	J:204097
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IDA	J:204097
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:143610
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:4645
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:38502
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:4645
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0051425	PTB domain binding	ISO	J:164563
Molecular Function	GO:0005198	structural molecule activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005901	caveola	IDA	J:129658
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0005899	insulin receptor complex	ISO	J:164563
Cellular Component	GO:0005899	insulin receptor complex	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:46223
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0031981	nuclear lumen	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:326513
Cellular Component	GO:0005886	plasma membrane	IDA	J:32474
Cellular Component	GO:0005886	plasma membrane	IDA	J:204994
Cellular Component	GO:0005886	plasma membrane	IDA	J:89969
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0060417	yolk	ISO	J:155856
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0030325	adrenal gland development	IGI	J:197599
Biological Process	GO:0097242	amyloid-beta clearance	ISO	J:155856
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:79280
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:153971
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0097062	dendritic spine maintenance	ISO	J:155856
Biological Process	GO:0008544	epidermis development	IMP	J:199282
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:79280
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	IBA	J:265628
Biological Process	GO:0003007	heart morphogenesis	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:143610
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:326513
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:4645
Biological Process	GO:0008286	insulin receptor signaling pathway	IGI	J:38502
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:204097
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:204097
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:4645
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:80826
Biological Process	GO:0008584	male gonad development	IGI	J:197599
Biological Process	GO:0030238	male sex determination	IMP	J:86618
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0032410	negative regulation of transporter activity	ISO	J:155856
Biological Process	GO:1990535	neuron projection maintenance	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	IDA	J:53105
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0048639	positive regulation of developmental growth	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:197599
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	IMP	J:158405
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0045821	positive regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0010560	positive regulation of glycoprotein biosynthetic process	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0051446	positive regulation of meiotic cell cycle	IGI	J:197599
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IMP	J:199282
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0043243	positive regulation of protein-containing complex disassembly	ISO	J:155856
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0060267	positive regulation of respiratory burst	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0031623	receptor internalization	IDA	J:326634
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045995	regulation of embryonic development	ISO	J:164563
Biological Process	GO:2000194	regulation of female gonad development	IGI	J:197599
Biological Process	GO:0010310	regulation of hydrogen peroxide metabolic process	ISO	J:155856
Biological Process	GO:0031667	response to nutrient levels	ISO	J:155856
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563