GO Annotations Graph

• Symbol: Il2ra
• Name: interleukin 2 receptor, alpha chain
• ID: MGI:96549

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019976	interleukin-2 binding	IBA	J:265628
Molecular Function	GO:0019976	interleukin-2 binding	IPI	J:16175
Molecular Function	GO:0019976	interleukin-2 binding	IPI	J:16175
Molecular Function	GO:0004911	interleukin-2 receptor activity	ISO	J:164563
Molecular Function	GO:0004911	interleukin-2 receptor activity	ISO	J:164563
Molecular Function	GO:0004911	interleukin-2 receptor activity	ISO	J:155856
Molecular Function	GO:0004911	interleukin-2 receptor activity	IMP	J:64279
Molecular Function	GO:0005515	protein binding	IPI	J:168252
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:35057
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92334
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:172134
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:91939
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:53400
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:96628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:174697
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:98417
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:112602
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:61649
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92679
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:99189
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141227
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:137854
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:152384
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:118845
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:14194
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:64279
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:144049
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:16175
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:89706
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:34311
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:155686
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:17350
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:140498
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:89322
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:177992
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:139262
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29796
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:64279
Biological Process	GO:0006924	activation-induced cell death of T cells	IMP	J:64279
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	ISO	J:155856
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:64279
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:84826
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:84826
Biological Process	GO:0007219	Notch signaling pathway	IGI	J:174697
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IMP	J:64279
Biological Process	GO:0045582	positive regulation of T cell differentiation	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:2000561	regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:112602
Biological Process	GO:0046013	regulation of T cell homeostatic proliferation	IMP	J:112602
Biological Process	GO:0002664	regulation of T cell tolerance induction	ISO	J:164563
Biological Process	GO:0043029	T cell homeostasis	IMP	J:84826