Igf1r GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Igf1r
insulin-like growth factor I receptor
MGI:96433

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043559	insulin binding	ISO	J:164563
Molecular Function	GO:0005009	insulin receptor activity	IBA	J:265628
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:164563
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:155856
Molecular Function	GO:0043560	insulin receptor substrate binding	IBA	J:265628
Molecular Function	GO:0005520	insulin-like growth factor binding	ISO	J:164563
Molecular Function	GO:0005520	insulin-like growth factor binding	IPI	J:86296
Molecular Function	GO:0031994	insulin-like growth factor I binding	ISO	J:164563
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	ISO	J:164563
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	ISO	J:155856
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	IGI	J:307414
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	IGI	J:307414
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	IDA	J:290858
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	IGI	J:307414
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	IGI	J:38307
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:327223
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:81182
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:327223
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:85099
Molecular Function	GO:0005515	protein binding	IPI	J:86675
Molecular Function	GO:0005515	protein binding	IPI	J:85099
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0140318	protein transporter activity	ISO	J:164563
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IGI	J:307414
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IGI	J:307414
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IDA	J:290858
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IGI	J:307414
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:38307
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:327223
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:81182
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:327223
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005198	structural molecule activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72247
Cellular Component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:253231
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:253231
Cellular Component	GO:0005899	insulin receptor complex	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:18719
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:134608
Cellular Component	GO:0005886	plasma membrane	IDA	J:201107
Cellular Component	GO:1902911	protein kinase complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:201107
Biological Process	GO:0030325	adrenal gland development	IGI	J:197599
Biological Process	GO:0097242	amyloid-beta clearance	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:79280
Biological Process	GO:0007409	axonogenesis	ISO	J:155856
Biological Process	GO:0007420	brain development	IMP	J:84857
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0071333	cellular response to glucose stimulus	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	IMP	J:186813
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:186813
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0021549	cerebellum development	ISO	J:155856
Biological Process	GO:0097062	dendritic spine maintenance	ISO	J:155856
Biological Process	GO:0008544	epidermis development	IMP	J:199282
Biological Process	GO:0030010	establishment of cell polarity	ISO	J:155856
Biological Process	GO:0044849	estrous cycle	ISO	J:155856
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:79280
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:38307
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:294899
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:15108
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:42756
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:42756
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:81182
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:290858
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:288213
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:327403
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IC	J:85099
Biological Process	GO:0030238	male sex determination	IMP	J:86618
Biological Process	GO:0030879	mammary gland development	IMP	J:124667
Biological Process	GO:0000165	MAPK cascade	IMP	J:134608
Biological Process	GO:0000165	MAPK cascade	IMP	J:134608
Biological Process	GO:0140014	mitotic nuclear division	IMP	J:199282
Biological Process	GO:0140014	mitotic nuclear division	IMP	J:199282
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1904193	negative regulation of cholangiocyte apoptotic process	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IMP	J:199282
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	ISO	J:155856
Biological Process	GO:0043409	negative regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:134608
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:134608
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	IDA	J:53105
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:151496
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0048680	positive regulation of axon regeneration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:234372
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:155856
Biological Process	GO:0048639	positive regulation of developmental growth	IMP	J:197599
Biological Process	GO:0051054	positive regulation of DNA metabolic process	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:197599
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:134608
Biological Process	GO:0051446	positive regulation of meiotic cell cycle	IGI	J:197599
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IMP	J:199282
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:134608
Biological Process	GO:0043243	positive regulation of protein-containing complex disassembly	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	ISO	J:155856
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:253231
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	EXP	J:253231
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	IMP	J:134608
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:134608
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:134608
Biological Process	GO:0006468	protein phosphorylation	IDA	J:131821
Biological Process	GO:0046328	regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0046328	regulation of JNK cascade	IBA	J:265628
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:1902065	response to L-glutamate	ISO	J:155856
Biological Process	GO:0045056	transcytosis	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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