GO Annotations Graph

• Symbol: Hk1
• Name: hexokinase 1
• ID: MGI:96103

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0008865	fructokinase activity	ISO	J:155856
Molecular Function	GO:0008865	fructokinase activity	IBA	J:265628
Molecular Function	GO:0004340	glucokinase activity	ISO	J:155856
Molecular Function	GO:0004340	glucokinase activity	IBA	J:265628
Molecular Function	GO:0004340	glucokinase activity	IDA	J:140897
Molecular Function	GO:0005536	glucose binding	ISO	J:155856
Molecular Function	GO:0004396	hexokinase activity	ISO	J:164563
Molecular Function	GO:0004396	hexokinase activity	ISO	J:155856
Molecular Function	GO:0004396	hexokinase activity	IMP	J:234642
Molecular Function	GO:0004396	hexokinase activity	IDA	J:92699
Molecular Function	GO:0004396	hexokinase activity	TAS	J:80475
Molecular Function	GO:0004396	hexokinase activity	IDA	J:132397
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0019158	mannokinase activity	ISO	J:155856
Molecular Function	GO:0019158	mannokinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042834	peptidoglycan binding	IDA	J:234642
Molecular Function	GO:0042834	peptidoglycan binding	ISO	J:164563
Molecular Function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:159554
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:234642
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:80475
Cellular Component	GO:0005829	cytosol	IDA	J:80475
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	IDA	J:149637
Cellular Component	GO:0005741	mitochondrial outer membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IDA	J:234642
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0061621	canonical glycolysis	IDA	J:318723
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:0046835	carbohydrate phosphorylation	ISO	J:164563
Biological Process	GO:0046835	carbohydrate phosphorylation	ISO	J:155856
Biological Process	GO:0046835	carbohydrate phosphorylation	IMP	J:234642
Biological Process	GO:0046835	carbohydrate phosphorylation	IDA	J:132397
Biological Process	GO:0046835	carbohydrate phosphorylation	IBA	J:265628
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	ISO	J:164563
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	ISO	J:155856
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	ISO	J:155856
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	IBA	J:265628
Biological Process	GO:0006006	glucose metabolic process	IBA	J:265628
Biological Process	GO:0006096	glycolytic process	ISO	J:155856
Biological Process	GO:0006096	glycolytic process	IBA	J:265628
Biological Process	GO:0006096	glycolytic process	TAS	J:80475
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0001678	intracellular glucose homeostasis	IBA	J:265628
Biological Process	GO:0072656	maintenance of protein location in mitochondrion	ISO	J:164563
Biological Process	GO:0006013	mannose metabolic process	ISO	J:155856
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	IDA	J:234642
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:234642
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0010359	regulation of anion channel activity	ISO	J:155856
Biological Process	GO:0002931	response to ischemia	ISO	J:155856