GO Annotations Graph

• Symbol: Fcer1a
• Name: Fc receptor, IgE, high affinity I, alpha polypeptide
• ID: MGI:95494

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019768	high-affinity IgE receptor activity	ISO	J:164563
Molecular Function	GO:0019863	IgE binding	ISO	J:164563
Molecular Function	GO:0019863	IgE binding	IMP	J:39250
Molecular Function	GO:0019863	IgE binding	IDA	J:31359
Molecular Function	GO:0019767	IgE receptor activity	IDA	J:37676
Molecular Function	GO:0019767	IgE receptor activity	IMP	J:39250
Molecular Function	GO:0005515	protein binding	IPI	J:16376
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:37676
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31359
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	TAS	J:78594
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:31359
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:37676
Biological Process	GO:0007166	cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:37676
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:39250
Biological Process	GO:0043308	eosinophil degranulation	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:37676
Biological Process	GO:0038095	Fc-epsilon receptor signaling pathway	IMP	J:39250
Biological Process	GO:0032604	granulocyte macrophage colony-stimulating factor production	IDA	J:37676
Biological Process	GO:0032632	interleukin-3 production	IDA	J:37676
Biological Process	GO:0019370	leukotriene biosynthetic process	IDA	J:37676
Biological Process	GO:0032762	mast cell cytokine production	IDA	J:37676
Biological Process	GO:0032762	mast cell cytokine production	IDA	J:37676
Biological Process	GO:0043303	mast cell degranulation	ISO	J:164563
Biological Process	GO:0043303	mast cell degranulation	IDA	J:37676
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:37676
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IDA	J:37676
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IDA	J:37676
Biological Process	GO:0032752	positive regulation of interleukin-3 production	IDA	J:37676
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:37676
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:37676
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	IDA	J:37676
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	IDA	J:37676
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IDA	J:37676
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:16376
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:37676
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	IMP	J:39250
Biological Process	GO:0001820	serotonin secretion	IDA	J:37676
Biological Process	GO:0001820	serotonin secretion	IMP	J:39250
Biological Process	GO:0007165	signal transduction	IDA	J:78594
Biological Process	GO:0042092	type 2 immune response	ISO	J:164563
Biological Process	GO:0016068	type I hypersensitivity	ISO	J:164563