GO Annotations Graph

• Symbol: Cd40lg
• Name: CD40 ligand
• ID: MGI:88337

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005174	CD40 receptor binding	ISO	J:155856
Molecular Function	GO:0005174	CD40 receptor binding	ISO	J:164563
Molecular Function	GO:0005174	CD40 receptor binding	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	IEA	J:72247
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:140498
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0030183	B cell differentiation	IGI	J:87846
Biological Process	GO:0042100	B cell proliferation	ISO	J:164563
Biological Process	GO:0023035	CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0097028	dendritic cell differentiation	ISO	J:155856
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002377	immunoglobulin production	IGI	J:93923
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045190	isotype switching	IDA	J:113688
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030168	platelet activation	ISO	J:164563
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:155856
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	ISO	J:155856
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	ISO	J:155856
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:155856
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:155856
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032753	positive regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:155856
Biological Process	GO:0002637	regulation of immunoglobulin production	IDA	J:86592
Biological Process	GO:0007165	signal transduction	NAS	J:113688