Bdnf GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Bdnf
brain derived neurotrophic factor
MGI:88145

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005163	nerve growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0005169	neurotrophin TRKB receptor binding	ISO	J:155856
Molecular Function	GO:0005169	neurotrophin TRKB receptor binding	ISO	J:324065
Molecular Function	GO:0005515	protein binding	IPI	J:209132
Molecular Function	GO:0005515	protein binding	IPI	J:72304
Molecular Function	GO:0005102	signaling receptor binding	IEA	J:72247
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:161262
Cellular Component	GO:0005737	cytoplasm	IDA	J:196246
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:91294
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:87385
Cellular Component	GO:0030425	dendrite	IDA	J:161262
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181822
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-204967
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-205099
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9006144
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9032771
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:161262
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:161262
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:161262
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:161262
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:185053
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:185053
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:185053
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:185053
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:196246
Cellular Component	GO:0030141	secretory granule	IDA	J:209132
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IBA	J:265628
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0048675	axon extension	IDA	J:201826
Biological Process	GO:0007411	axon guidance	IMP	J:109712
Biological Process	GO:0007412	axon target recognition	IMP	J:94276
Biological Process	GO:0007412	axon target recognition	IMP	J:94276
Biological Process	GO:0001662	behavioral fear response	IMP	J:91563
Biological Process	GO:0048148	behavioral response to cocaine	ISO	J:155856
Biological Process	GO:0071229	cellular response to acid chemical	IDA	J:219199
Biological Process	GO:0007623	circadian rhythm	IEP	J:199564
Biological Process	GO:0048668	collateral sprouting	ISO	J:164563
Biological Process	GO:1990708	conditioned place preference	ISO	J:155856
Biological Process	GO:0016358	dendrite development	IMP	J:84683
Biological Process	GO:0097484	dendrite extension	IDA	J:201826
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0042596	fear response	IMP	J:91563
Biological Process	GO:0007631	feeding behavior	IMP	J:84073
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	IDA	J:116460
Biological Process	GO:0014047	glutamate secretion	IPI	J:111724
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:207770
Biological Process	GO:0048839	inner ear development	IMP	J:26749
Biological Process	GO:0007612	learning	ISO	J:155856
Biological Process	GO:0007611	learning or memory	IMP	J:91563
Biological Process	GO:0042490	mechanoreceptor differentiation	IGI	J:93853
Biological Process	GO:0042490	mechanoreceptor differentiation	IGI	J:93853
Biological Process	GO:0007613	memory	IBA	J:265628
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:84857
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IGI	J:274420
Biological Process	GO:0010832	negative regulation of myotube differentiation	ISO	J:155856
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	IDA	J:83933
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IBA	J:265628
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:32557
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:101073
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0043069	negative regulation of programmed cell death	IMP	J:206879
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	ISO	J:155856
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	IDA	J:116460
Biological Process	GO:0021675	nerve development	IBA	J:265628
Biological Process	GO:0021675	nerve development	IMP	J:26749
Biological Process	GO:0038180	nerve growth factor signaling pathway	IBA	J:265628
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:32557
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:101073
Biological Process	GO:1990138	neuron projection extension	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	IBA	J:265628
Biological Process	GO:0008038	neuron recognition	IMP	J:98393
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:204740
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:204740
Biological Process	GO:0048672	positive regulation of collateral sprouting	ISO	J:164563
Biological Process	GO:0048672	positive regulation of collateral sprouting	IBA	J:265628
Biological Process	GO:0048672	positive regulation of collateral sprouting	IMP	J:209132
Biological Process	GO:0048672	positive regulation of collateral sprouting	IDA	J:209132
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:73065
Biological Process	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	ISO	J:73065
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:83933
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:274420
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:204740
Biological Process	GO:1900122	positive regulation of receptor binding	ISO	J:155856
Biological Process	GO:1900122	positive regulation of receptor binding	ISO	J:164563
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:164563
Biological Process	GO:0031099	regeneration	ISO	J:155856
Biological Process	GO:0030516	regulation of axon extension	ISO	J:155856
Biological Process	GO:0048670	regulation of collateral sprouting	IGI	J:209132
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0043523	regulation of neuron apoptotic process	IDA	J:107643
Biological Process	GO:0045664	regulation of neuron differentiation	IBA	J:265628
Biological Process	GO:0046668	regulation of retinal cell programmed cell death	IDA	J:73377
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	IDA	J:111724
Biological Process	GO:0048167	regulation of synaptic plasticity	IDA	J:119836
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:91563
Biological Process	GO:0099083	retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission	IMP	J:161262
Biological Process	GO:0007416	synapse assembly	ISO	J:164563
Biological Process	GO:0061193	taste bud development	IMP	J:206879
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	EXP	J:161262
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA	J:161262
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA	J:161262
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA	J:161262
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0001657	ureteric bud development	IDA	J:100569

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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