Apoe GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Apoe
apolipoprotein E
MGI:88057

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:155856
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0001540	amyloid-beta binding	IBA	J:265628
Molecular Function	GO:0016209	antioxidant activity	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	IDA	J:93331
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	ISO	J:164563
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	IDA	J:201440
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0046848	hydroxyapatite binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0005319	lipid transporter activity	ISO	J:155856
Molecular Function	GO:0005319	lipid transporter activity	ISO	J:164563
Molecular Function	GO:0071813	lipoprotein particle binding	IDA	J:71838
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	IBA	J:265628
Molecular Function	GO:0046911	metal chelating activity	ISO	J:164563
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	IMP	J:150395
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:287730
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0042627	chylomicron	ISO	J:164563
Cellular Component	GO:0042627	chylomicron	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0034365	discoidal high-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2173779
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:203564
Cellular Component	GO:0005615	extracellular space	IDA	J:155809
Cellular Component	GO:0005615	extracellular space	IDA	J:93331
Cellular Component	GO:0005615	extracellular space	IDA	J:42632
Cellular Component	GO:0005615	extracellular space	IDA	J:40819
Cellular Component	GO:0005615	extracellular space	IDA	J:22362
Cellular Component	GO:0031232	extrinsic component of external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:235715
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235715
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:235715
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0034364	high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034364	high-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	IBA	J:265628
Cellular Component	GO:0005770	late endosome	ISO	J:155856
Cellular Component	GO:1990777	lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034362	low-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0034362	low-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034362	low-density lipoprotein particle	IDA	J:150395
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0042470	melanosome	ISO	J:164563
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0097487	multivesicular body, internal vesicle	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0043083	synaptic cleft	ISO	J:164563
Cellular Component	GO:0034361	very-low-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0034361	very-low-density lipoprotein particle	ISO	J:164563
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0097113	AMPA glutamate receptor clustering	ISO	J:164563
Biological Process	GO:0042982	amyloid precursor protein metabolic process	ISO	J:164563
Biological Process	GO:0048844	artery morphogenesis	IGI	J:116827
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0006707	cholesterol catabolic process	IBA	J:265628
Biological Process	GO:0006707	cholesterol catabolic process	IMP	J:51282
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0033344	cholesterol efflux	IDA	J:93331
Biological Process	GO:0033344	cholesterol efflux	IMP	J:72104
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:202115
Biological Process	GO:0042632	cholesterol homeostasis	IGI	J:66424
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:2809
Biological Process	GO:0042632	cholesterol homeostasis	IGI	J:116827
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:22362
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:2809
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:76988
Biological Process	GO:0034382	chylomicron remnant clearance	ISO	J:164563
Biological Process	GO:0072359	circulatory system development	IMP	J:159593
Biological Process	GO:0055089	fatty acid homeostasis	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010467	gene expression	IGI	J:243332
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ISO	J:164563
Biological Process	GO:0034384	high-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0071831	intermediate-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IDA	J:18071
Biological Process	GO:0055088	lipid homeostasis	IMP	J:129977
Biological Process	GO:0006629	lipid metabolic process	IGI	J:66424
Biological Process	GO:0006869	lipid transport	ISO	J:155856
Biological Process	GO:0010877	lipid transport involved in lipid storage	IMP	J:202115
Biological Process	GO:0042158	lipoprotein biosynthetic process	ISO	J:164563
Biological Process	GO:0042158	lipoprotein biosynthetic process	IGI	J:121045
Biological Process	GO:0042159	lipoprotein catabolic process	IBA	J:265628
Biological Process	GO:0042159	lipoprotein catabolic process	IMP	J:129977
Biological Process	GO:0042157	lipoprotein metabolic process	ISO	J:155856
Biological Process	GO:0042157	lipoprotein metabolic process	IGI	J:66424
Biological Process	GO:0042157	lipoprotein metabolic process	IMP	J:51022
Biological Process	GO:0042157	lipoprotein metabolic process	IGI	J:87974
Biological Process	GO:0035641	locomotory exploration behavior	ISO	J:164563
Biological Process	GO:0015909	long-chain fatty acid transport	ISO	J:164563
Biological Process	GO:0007616	long-term memory	ISO	J:164563
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	IMP	J:150395
Biological Process	GO:0051651	maintenance of location in cell	IMP	J:129977
Biological Process	GO:0032438	melanosome organization	IMP	J:315405
Biological Process	GO:0032438	melanosome organization	ISO	J:164563
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	IMP	J:107702
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0030195	negative regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process	ISO	J:155856
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0090370	negative regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0061000	negative regulation of dendritic spine development	ISO	J:164563
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	ISO	J:164563
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:259124
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:179147
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process	ISO	J:164563
Biological Process	GO:1903001	negative regulation of lipid transport across blood-brain barrier	ISO	J:164563
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	ISO	J:164563
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IBA	J:265628
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:164563
Biological Process	GO:1902999	negative regulation of phospholipid efflux	ISO	J:164563
Biological Process	GO:0010544	negative regulation of platelet activation	ISO	J:164563
Biological Process	GO:1901627	negative regulation of postsynaptic membrane organization	ISO	J:164563
Biological Process	GO:0051248	negative regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IGI	J:136168
Biological Process	GO:0090209	negative regulation of triglyceride metabolic process	IGI	J:41982
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0007263	nitric oxide mediated signal transduction	ISO	J:164563
Biological Process	GO:0097114	NMDA glutamate receptor clustering	ISO	J:164563
Biological Process	GO:0033700	phospholipid efflux	ISO	J:164563
Biological Process	GO:0044794	positive regulation by host of viral process	ISO	J:164563
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:107702
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IMP	J:292426
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	IMP	J:150395
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	IMP	J:150395
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	ISO	J:164563
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:164563
Biological Process	GO:1902952	positive regulation of dendritic spine maintenance	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1905855	positive regulation of heparan sulfate binding	ISO	J:164563
Biological Process	GO:1905860	positive regulation of heparan sulfate proteoglycan binding	ISO	J:164563
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	ISO	J:164563
Biological Process	GO:1903002	positive regulation of lipid transport across blood-brain barrier	ISO	J:164563
Biological Process	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:1902998	positive regulation of neurofibrillary tangle assembly	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	IMP	J:239196
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	IBA	J:265628
Biological Process	GO:1902995	positive regulation of phospholipid efflux	ISO	J:164563
Biological Process	GO:1901631	positive regulation of presynaptic membrane organization	ISO	J:164563
Biological Process	GO:0017038	protein import	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:1905906	regulation of amyloid fibril formation	ISO	J:164563
Biological Process	GO:1902991	regulation of amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1900221	regulation of amyloid-beta clearance	ISO	J:164563
Biological Process	GO:1900221	regulation of amyloid-beta clearance	IBA	J:265628
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:266110
Biological Process	GO:2000822	regulation of behavioral fear response	ISO	J:164563
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:1905890	regulation of cellular response to very-low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0090181	regulation of cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:129977
Biological Process	GO:0010468	regulation of gene expression	IMP	J:129977
Biological Process	GO:0010468	regulation of gene expression	IMP	J:129977
Biological Process	GO:0010468	regulation of gene expression	IMP	J:129977
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:266110
Biological Process	GO:1901214	regulation of neuron death	ISO	J:164563
Biological Process	GO:0097006	regulation of plasma lipoprotein particle levels	IMP	J:202115
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0051246	regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0050807	regulation of synapse organization	IDA	J:235715
Biological Process	GO:0050807	regulation of synapse organization	IDA	J:235715
Biological Process	GO:0050807	regulation of synapse organization	IMP	J:235715
Biological Process	GO:1902947	regulation of tau-protein kinase activity	ISO	J:164563
Biological Process	GO:0090207	regulation of triglyceride metabolic process	ISO	J:155856
Biological Process	GO:0061771	response to caloric restriction	ISO	J:164563
Biological Process	GO:0002021	response to dietary excess	IMP	J:129977
Biological Process	GO:0006979	response to oxidative stress	IMP	J:33429
Biological Process	GO:0043691	reverse cholesterol transport	ISO	J:164563
Biological Process	GO:0070328	triglyceride homeostasis	IMP	J:202115
Biological Process	GO:0070328	triglyceride homeostasis	IMP	J:201440
Biological Process	GO:0006641	triglyceride metabolic process	ISO	J:164563
Biological Process	GO:0071830	triglyceride-rich lipoprotein particle clearance	IMP	J:201440
Biological Process	GO:0071830	triglyceride-rich lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0042311	vasodilation	IMP	J:51282
Biological Process	GO:0034447	very-low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	IMP	J:150395
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0019068	virion assembly	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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