Acvr1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Acvr1
activin A receptor, type 1
MGI:87911

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0048185	activin binding	IPI	J:11226
Molecular Function	GO:0048185	activin binding	IPI	J:27756
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:164563
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:155856
Molecular Function	GO:0016361	activin receptor activity, type I	IDA	J:69633
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IDA	J:25557
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:93750
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	IDA	J:77383
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	IBA	J:265628
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	IDA	J:25557
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Cellular Component	GO:0048179	activin receptor complex	ISO	J:155856
Cellular Component	GO:0048179	activin receptor complex	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IDA	J:61348
Cellular Component	GO:0045177	apical part of cell	IDA	J:68348
Cellular Component	GO:0070724	BMP receptor complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:69633
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002526	acute inflammatory response	IEP	J:116258
Biological Process	GO:0003289	atrial septum primum morphogenesis	ISO	J:164563
Biological Process	GO:0003289	atrial septum primum morphogenesis	IMP	J:103532
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:103532
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	IMP	J:103532
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:119667
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:119667
Biological Process	GO:0060923	cardiac muscle cell fate commitment	ISO	J:164563
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:95020
Biological Process	GO:0009953	dorsal/ventral pattern formation	IBA	J:265628
Biological Process	GO:0009790	embryo development	IMP	J:87407
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0003143	embryonic heart tube morphogenesis	ISO	J:164563
Biological Process	GO:0061445	endocardial cushion cell fate commitment	ISO	J:164563
Biological Process	GO:0003274	endocardial cushion fusion	IMP	J:103532
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:103532
Biological Process	GO:0007369	gastrulation	IMP	J:54394
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:117234
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:117234
Biological Process	GO:0007281	germ cell development	IMP	J:91660
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:119667
Biological Process	GO:0007507	heart development	IMP	J:90988
Biological Process	GO:0007507	heart development	IMP	J:103532
Biological Process	GO:0001701	in utero embryonic development	IMP	J:90453
Biological Process	GO:0001701	in utero embryonic development	IMP	J:87407
Biological Process	GO:0001701	in utero embryonic development	IMP	J:117234
Biological Process	GO:0001701	in utero embryonic development	IMP	J:90453
Biological Process	GO:0001701	in utero embryonic development	IMP	J:117234
Biological Process	GO:0007498	mesoderm development	IMP	J:117234
Biological Process	GO:0007498	mesoderm development	IMP	J:117234
Biological Process	GO:0001707	mesoderm formation	IMP	J:117234
Biological Process	GO:0001707	mesoderm formation	IMP	J:57670
Biological Process	GO:0001707	mesoderm formation	IMP	J:117234
Biological Process	GO:0003183	mitral valve morphogenesis	ISO	J:164563
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	ISO	J:164563
Biological Process	GO:0001755	neural crest cell migration	IMP	J:90988
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0060037	pharyngeal system development	IMP	J:119667
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:2000017	positive regulation of determination of dorsal identity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:103532
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:103532
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:103532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0030278	regulation of ossification	ISO	J:164563
Biological Process	GO:0051145	smooth muscle cell differentiation	IMP	J:119667
Biological Process	GO:0051145	smooth muscle cell differentiation	IMP	J:119667
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TAS	J:77383
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:69633
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0001655	urogenital system development	ISO	J:73065
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:103532

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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