GO Annotations Graph

• Symbol: Rapgef2
• Name: Rap guanine nucleotide exchange factor (GEF) 2
• ID: MGI:2659071

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031697	beta-1 adrenergic receptor binding	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:198912
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:152727
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:201420
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0070300	phosphatidic acid binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0050699	WW domain binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	IBA	J:265628
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001568	blood vessel development	IMP	J:125199
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0019933	cAMP-mediated signaling	IDA	J:201420
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071320	cellular response to cAMP	IMP	J:198912
Biological Process	GO:0071320	cellular response to cAMP	IDA	J:201420
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071321	cellular response to cGMP	ISO	J:164563
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:155856
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	ISO	J:164563
Biological Process	GO:0021884	forebrain neuron development	IMP	J:149445
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:201420
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030033	microvillus assembly	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:198912
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	IMP	J:198912
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	ISO	J:164563
Biological Process	GO:0048022	negative regulation of melanin biosynthetic process	IMP	J:198912
Biological Process	GO:0038180	nerve growth factor signaling pathway	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001764	neuron migration	IMP	J:178740
Biological Process	GO:0031175	neuron projection development	IMP	J:201420
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	IDA	J:201420
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	IMP	J:198912
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	ISO	J:164563
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	IMP	J:198912
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:201420
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:198912
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IDA	J:201420
Biological Process	GO:0043547	positive regulation of GTPase activity	IMP	J:198912
Biological Process	GO:0043547	positive regulation of GTPase activity	IMP	J:152727
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:2001224	positive regulation of neuron migration	IMP	J:149445
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	IDA	J:201420
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:201420
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:2001214	positive regulation of vasculogenesis	IMP	J:152727
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0032486	Rap protein signal transduction	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:1901888	regulation of cell junction assembly	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IEA	J:72247
Biological Process	GO:0048167	regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0021591	ventricular system development	IMP	J:125199