GO Annotations Graph

• Symbol: Smcr8
• Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
• ID: MGI:2444720

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	IEA	J:72247
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:237194
Molecular Function	GO:0005515	protein binding	IPI	J:292854
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	ISO	J:164563
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	NAS	J:236977
Cellular Component	GO:0005737	cytoplasm	IDA	J:236977
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	ISO	J:164563
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0098794	postsynapse	IDA	J:292854
Cellular Component	GO:0098793	presynapse	IDA	J:292854
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:1902902	negative regulation of autophagosome assembly	ISO	J:164563
Biological Process	GO:0045920	negative regulation of exocytosis	NAS	J:272433
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0050777	negative regulation of immune response	NAS	J:272433
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:1901098	positive regulation of autophagosome maturation	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	IMP	J:236977
Biological Process	GO:0010506	regulation of autophagy	NAS	J:236977
Biological Process	GO:1903432	regulation of TORC1 signaling	ISO	J:164563