GO Annotations Graph

• Symbol: Cyb5r4
• Name: cytochrome b5 reductase 4
• ID: MGI:2386848

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	ISO	J:164563
Molecular Function	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	ISO	J:59088
Molecular Function	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	IDA	J:91615
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:155856
Molecular Function	GO:0020037	heme binding	ISO	J:155856
Molecular Function	GO:0020037	heme binding	IBA	J:265628
Molecular Function	GO:0020037	heme binding	ISO	J:59088
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003958	NADPH-hemoprotein reductase activity	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:89525
Molecular Function	GO:0005515	protein binding	IPI	J:89525
Cellular Component	GO:0005737	cytoplasm	ISO	J:59088
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:91615
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0048468	cell development	IMP	J:91486
Biological Process	GO:0006091	generation of precursor metabolites and energy	ISO	J:164563
Biological Process	GO:0006091	generation of precursor metabolites and energy	IBA	J:265628
Biological Process	GO:0042593	glucose homeostasis	IMP	J:91486
Biological Process	GO:0042168	heme metabolic process	ISO	J:59088
Biological Process	GO:0030073	insulin secretion	IMP	J:91486
Biological Process	GO:0006739	NADP metabolic process	ISO	J:155856
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0046677	response to antibiotic	IMP	J:122859
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:164563
Biological Process	GO:0006801	superoxide metabolic process	IBA	J:265628