GO Annotations Graph

• Symbol: Aph1a
• Name: aph1 homolog A, gamma secretase subunit
• ID: MGI:2385110

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0061133	endopeptidase activator activity	IMP	J:297314
Molecular Function	GO:0061133	endopeptidase activator activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:297314
Molecular Function	GO:0008233	peptidase activity	ISA	J:80170
Molecular Function	GO:0005515	protein binding	IPI	J:177000
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IBA	J:265628
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0070765	gamma-secretase complex	ISO	J:164563
Cellular Component	GO:0070765	gamma-secretase complex	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISA	J:80170
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-209285
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0042982	amyloid precursor protein metabolic process	ISO	J:164563
Biological Process	GO:0034205	amyloid-beta formation	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	ISO	J:164563
Biological Process	GO:0001656	metanephros development	IMP	J:85474
Biological Process	GO:0007220	Notch receptor processing	NAS	J:54336
Biological Process	GO:0007220	Notch receptor processing	ISO	J:164563
Biological Process	GO:0007220	Notch receptor processing	IBA	J:265628
Biological Process	GO:0007220	Notch receptor processing	IMP	J:157933
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0010950	positive regulation of endopeptidase activity	IMP	J:297314
Biological Process	GO:0010950	positive regulation of endopeptidase activity	ISO	J:164563
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0016485	protein processing	IBA	J:265628
Biological Process	GO:0016485	protein processing	ISA	J:80170