GO Annotations Graph

• Symbol: Cblc
• Name: Cbl proto-oncogene c
• ID: MGI:1931457

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:66945
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:66945
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	IBA	J:265628
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0023051	regulation of signaling	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:66945