GO Annotations Graph

• Symbol: Nampt
• Name: nicotinamide phosphoribosyltransferase
• ID: MGI:1929865

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0016757	glycosyltransferase activity	IEA	J:60000
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:245283
Molecular Function	GO:0042802	identical protein binding	IPI	J:245271
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0047280	nicotinamide phosphoribosyltransferase activity	ISO	J:155856
Molecular Function	GO:0047280	nicotinamide phosphoribosyltransferase activity	IBA	J:265628
Molecular Function	GO:0047280	nicotinamide phosphoribosyltransferase activity	IDA	J:94904
Molecular Function	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:94904
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1368914
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:147991
Biological Process	GO:0007623	circadian rhythm	IEP	J:147991
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0009435	NAD biosynthetic process	IBA	J:265628
Biological Process	GO:0009435	NAD biosynthetic process	IDA	J:94904
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:155856
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:155856
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0019363	pyridine nucleotide biosynthetic process	IEA	J:60000
Biological Process	GO:0014916	regulation of lung blood pressure	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000