Pik3cb GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
MGI:1922019

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:155856
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IBA	J:265628
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IMP	J:98315
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IMP	J:109024
Molecular Function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:109024
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:109024
Molecular Function	GO:0016301	kinase activity	ISO	J:217701
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0035004	phosphatidylinositol 3-kinase activity	IEA	J:72247
Molecular Function	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA	J:72245
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:136236
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0106310	protein serine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:291522
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	ISO	J:155856
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0060055	angiogenesis involved in wound healing	IMP	J:214815
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0040016	embryonic cleavage	IMP	J:75617
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0001935	endothelial cell proliferation	IMP	J:214815
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IMP	J:98315
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:98315
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP	J:291522
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:291522
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:291522
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:291522
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IGI	J:161894
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IEA	J:72247
Biological Process	GO:0016310	phosphorylation	ISO	J:217701
Biological Process	GO:0030168	platelet activation	IMP	J:98315
Biological Process	GO:0010595	positive regulation of endothelial cell migration	IGI	J:161894
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:214815
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	IGI	J:161894
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	ISO	J:164563
Biological Process	GO:0001952	regulation of cell-matrix adhesion	IMP	J:98315
Biological Process	GO:0001952	regulation of cell-matrix adhesion	ISO	J:214815
Biological Process	GO:0002931	response to ischemia	IMP	J:291522
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	IGI	J:161894
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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