GO Annotations Graph

• Symbol: Opa1
• Name: OPA1, mitochondrial dynamin like GTPase
• ID: MGI:1921393

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1901612	cardiolipin binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISS	J:76355
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	TAS	J:76355
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0070300	phosphatidic acid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:254859
Molecular Function	GO:0005515	protein binding	IPI	J:173140
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:76355
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	IBA	J:265628
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IMP	J:116017
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:254859
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005758	mitochondrial intermembrane space	IDA	J:76355
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:164563
Cellular Component	GO:0031966	mitochondrial membrane	IBA	J:265628
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:113296
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:76355
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:72247
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0036444	calcium import into the mitochondrion	ISO	J:155856
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0046039	GTP metabolic process	ISO	J:164563
Biological Process	GO:0007007	inner mitochondrial membrane organization	ISO	J:164563
Biological Process	GO:0048312	intracellular distribution of mitochondria	ISO	J:155856
Biological Process	GO:0097749	membrane tubulation	ISO	J:164563
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:281198
Biological Process	GO:0008053	mitochondrial fusion	ISO	J:164563
Biological Process	GO:0008053	mitochondrial fusion	IBA	J:265628
Biological Process	GO:0000002	mitochondrial genome maintenance	ISO	J:164563
Biological Process	GO:0070584	mitochondrion morphogenesis	ISO	J:155856
Biological Process	GO:0007005	mitochondrion organization	NAS	J:76355
Biological Process	GO:0007005	mitochondrion organization	ISO	J:155856
Biological Process	GO:0007005	mitochondrion organization	ISO	J:73065
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:198144
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IMP	J:116017
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	IMP	J:116017
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:98216
Biological Process	GO:1900078	positive regulation of cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:1900006	positive regulation of dendrite development	ISO	J:155856
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0010636	positive regulation of mitochondrial fusion	ISO	J:155856
Biological Process	GO:0014042	positive regulation of neuron maturation	ISO	J:155856
Biological Process	GO:0051259	protein complex oligomerization	ISO	J:164563
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0007601	visual perception	ISO	J:164563