Trpm4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Trpm4
transient receptor potential cation channel, subfamily M, member 4
MGI:1915917

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:257315
Molecular Function	GO:0005227	calcium activated cation channel activity	IDA	J:166018
Molecular Function	GO:0005227	calcium activated cation channel activity	IDA	J:257315
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:155856
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:164563
Molecular Function	GO:0005227	calcium activated cation channel activity	IBA	J:265628
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:84761
Molecular Function	GO:0005262	calcium channel activity	IDA	J:84948
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0099604	ligand-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	ISO	J:84761
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:84761
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:257315
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9717432
Cellular Component	GO:0005886	plasma membrane	IDA	J:84948
Cellular Component	GO:0034706	sodium channel complex	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	IDA	J:84948
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0061337	cardiac conduction	IEA	J:72247
Biological Process	GO:0071318	cellular response to ATP	IDA	J:257315
Biological Process	GO:0002407	dendritic cell chemotaxis	IMP	J:140991
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0098662	inorganic cation transmembrane transport	IDA	J:257315
Biological Process	GO:0098662	inorganic cation transmembrane transport	ISO	J:164563
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	ISO	J:164563
Biological Process	GO:0086048	membrane depolarization during bundle of His cell action potential	ISO	J:164563
Biological Process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	IEA	J:72247
Biological Process	GO:0034220	monoatomic ion transmembrane transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0030502	negative regulation of bone mineralization	ISO	J:155856
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:1904179	positive regulation of adipose tissue development	ISO	J:155856
Biological Process	GO:1903949	positive regulation of atrial cardiac muscle cell action potential	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:1904199	positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	IDA	J:257315
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0016925	protein sumoylation	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:84761
Biological Process	GO:0002724	regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0098719	sodium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0042310	vasoconstriction	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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