GO Annotations Graph

• Symbol: Il21
• Name: interleukin 21
• ID: MGI:1890474

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005126	cytokine receptor binding	IDA	J:65629
Molecular Function	GO:0005134	interleukin-2 receptor binding	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Biological Process	GO:0001783	B cell apoptotic process	NAS	J:93740
Biological Process	GO:0048469	cell maturation	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IMP	J:190912
Biological Process	GO:0002314	germinal center B cell differentiation	IMP	J:190912
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0032613	interleukin-10 production	IDA	J:88003
Biological Process	GO:0032613	interleukin-10 production	IDA	J:88003
Biological Process	GO:0002370	natural killer cell cytokine production	IDA	J:88003
Biological Process	GO:0002370	natural killer cell cytokine production	IDA	J:88003
Biological Process	GO:0001779	natural killer cell differentiation	IDA	J:88003
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IDA	J:88003
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IDA	J:88003
Biological Process	GO:0045579	positive regulation of B cell differentiation	NAS	J:93740
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:190912
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IDA	J:88003
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	IDA	J:88003
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	IDA	J:88003
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IBA	J:265628
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IDA	J:88003
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:73065
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:88003
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:73065
Biological Process	GO:0061470	T follicular helper cell differentiation	IMP	J:190912
Biological Process	GO:0032609	type II interferon production	IDA	J:88003
Biological Process	GO:0032609	type II interferon production	IDA	J:88003
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	ISO	J:164563