Heyl GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Heyl
hairy/enhancer-of-split related with YRPW motif-like
MGI:1860511

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050683	AF-1 domain binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:175435
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISS	J:62860
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:101349
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0005515	protein binding	IPI	J:101349
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:175435
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:175435
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:185205
Cellular Component	GO:0005737	cytoplasm	IDA	J:175314
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2065441
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	ISS	J:58781
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IGI	J:133699
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	IGI	J:133699
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:133699
Biological Process	GO:0071773	cellular response to BMP stimulus	IEP	J:175435
Biological Process	GO:0072359	circulatory system development	IBA	J:265628
Biological Process	GO:0006351	DNA-templated transcription	ISS	J:62860
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:133699
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IGI	J:133699
Biological Process	GO:0032835	glomerulus development	IEP	J:97734
Biological Process	GO:0014031	mesenchymal cell development	IGI	J:133699
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:153555
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:101349
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:185205
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:175435
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:133699
Biological Process	GO:0007422	peripheral nervous system development	NAS	J:153555
Biological Process	GO:0045666	positive regulation of neuron differentiation	IMP	J:153555
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:175435
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:175435
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:133699
Biological Process	GO:0072014	proximal tubule development	IEP	J:97734
Biological Process	GO:0003184	pulmonary valve morphogenesis	IGI	J:133699
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISS	J:62860
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISS	J:58781
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISS	J:58781
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0060412	ventricular septum morphogenesis	IGI	J:133699

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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