GO Annotations Graph

• Symbol: Panx1
• Name: pannexin 1
• ID: MGI:1860055

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IPI	J:165948
Molecular Function	GO:0051015	actin filament binding	IDA	J:165948
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0015267	channel activity	IEA	J:72247
Molecular Function	GO:0005243	gap junction channel activity	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0022840	leak channel activity	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:157803
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005198	structural molecule activity	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0032059	bleb	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005921	gap junction	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:165948
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	ISO	J:155856
Biological Process	GO:0032610	interleukin-1 alpha production	IMP	J:136350
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:136350
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:136350
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:136350
Biological Process	GO:0006812	monoatomic cation transport	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	IMP	J:136350
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:136350
Biological Process	GO:0032732	positive regulation of interleukin-1 production	IEA	J:72247
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0033198	response to ATP	IMP	J:136350
Biological Process	GO:0002931	response to ischemia	IGI	J:180516