GO Annotations Graph

• Symbol: Dnmt3l
• Name: DNA methyltransferase 3-like
• ID: MGI:1859287

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0008047	enzyme activator activity	IBA	J:265628
Molecular Function	GO:0008047	enzyme activator activity	IDA	J:108227
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:73065
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISS	J:113944
Molecular Function	GO:0030234	enzyme regulator activity	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:123743
Molecular Function	GO:0005515	protein binding	IPI	J:206847
Molecular Function	GO:0005515	protein binding	IPI	J:245372
Molecular Function	GO:0005515	protein binding	IPI	J:123743
Molecular Function	GO:0005515	protein binding	IPI	J:295943
Molecular Function	GO:0005515	protein binding	IPI	J:128981
Molecular Function	GO:0005515	protein binding	IPI	J:75938
Molecular Function	GO:0005515	protein binding	IPI	J:128981
Molecular Function	GO:0005515	protein binding	IPI	J:75938
Molecular Function	GO:0005515	protein binding	IPI	J:108227
Cellular Component	GO:1902494	catalytic complex	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:108227
Cellular Component	GO:0005737	cytoplasm	IDA	J:108227
Cellular Component	GO:0005737	cytoplasm	IDA	J:75938
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:206847
Cellular Component	GO:0000792	heterochromatin	IDA	J:75938
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5334134
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336316
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336380
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336403
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:237199
Biological Process	GO:0090116	C-5 methylation of cytosine	ISO	J:164563
Biological Process	GO:0090116	C-5 methylation of cytosine	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	IMP	J:112884
Biological Process	GO:0006306	DNA methylation	IMP	J:225677
Biological Process	GO:0043046	DNA methylation involved in gamete generation	IMP	J:92661
Biological Process	GO:0032776	DNA methylation on cytosine	IMP	J:92661
Biological Process	GO:0071514	genomic imprinting	IMP	J:112884
Biological Process	GO:0001701	in utero embryonic development	IMP	J:75938
Biological Process	GO:0001701	in utero embryonic development	IMP	J:75938
Biological Process	GO:0007141	male meiosis I	IMP	J:92661
Biological Process	GO:0032259	methylation	IMP	J:112884
Biological Process	GO:1905642	negative regulation of DNA methylation	IMP	J:206847
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISS	J:113944
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:225677
Biological Process	GO:0001890	placenta development	IMP	J:112884
Biological Process	GO:1905643	positive regulation of DNA methylation	IMP	J:206847
Biological Process	GO:0010468	regulation of gene expression	IEA	J:72247
Biological Process	GO:0007283	spermatogenesis	IMP	J:92661
Biological Process	GO:0007283	spermatogenesis	IMP	J:225677
Biological Process	GO:0048863	stem cell differentiation	IMP	J:206847