GO Annotations Graph

• Symbol: Isg15
• Name: ISG15 ubiquitin-like modifier
• ID: MGI:1855694

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:207464
Molecular Function	GO:0005515	protein binding	IPI	J:304704
Molecular Function	GO:0005515	protein binding	IPI	J:305997
Molecular Function	GO:0005515	protein binding	IPI	J:304589
Molecular Function	GO:0005515	protein binding	IPI	J:296108
Molecular Function	GO:0005515	protein binding	IPI	J:94130
Molecular Function	GO:0031386	protein tag	ISO	J:164563
Molecular Function	GO:0031386	protein tag	IBA	J:265628
Molecular Function	GO:0031386	protein tag	IDA	J:100999
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0042742	defense response to bacterium	IMP	J:187590
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:119518
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0032020	ISG15-protein conjugation	IDA	J:178099
Biological Process	GO:0032020	ISG15-protein conjugation	ISO	J:164563
Biological Process	GO:0032020	ISG15-protein conjugation	IBA	J:265628
Biological Process	GO:0032020	ISG15-protein conjugation	IDA	J:100999
Biological Process	GO:0019941	modification-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0019941	modification-dependent protein catabolic process	IDA	J:94130
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045071	negative regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:169924
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	IMP	J:178099
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032461	positive regulation of protein oligomerization	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0070585	protein localization to mitochondrion	ISO	J:164563
Biological Process	GO:0032649	regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0034340	response to type I interferon	ISO	J:164563
Biological Process	GO:0009615	response to virus	ISO	J:164563