Prkn GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Prkn
parkin RBR E3 ubiquitin protein ligase
MGI:1355296

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0097602	cullin family protein binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:1990444	F-box domain binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:73065
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:104448
Molecular Function	GO:0005515	protein binding	IPI	J:171058
Molecular Function	GO:0005515	protein binding	IPI	J:306595
Molecular Function	GO:0005515	protein binding	IPI	J:116425
Molecular Function	GO:0005515	protein binding	IPI	J:212811
Molecular Function	GO:0005515	protein binding	IPI	J:180609
Molecular Function	GO:0005515	protein binding	IPI	J:213906
Molecular Function	GO:0005515	protein binding	IPI	J:259757
Molecular Function	GO:0005515	protein binding	IPI	J:259757
Molecular Function	GO:0005515	protein binding	IPI	J:156815
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0015631	tubulin binding	ISO	J:164563
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	ISO	J:164563
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:259757
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:73065
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:156815
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:1990381	ubiquitin-specific protease binding	ISO	J:164563
Cellular Component	GO:0016235	aggresome	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:207233
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0098691	dopaminergic synapse	IC	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IPI	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IEP	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IPI	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IEP	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IPI	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:260099
Cellular Component	GO:0098691	dopaminergic synapse	IPI	J:260099
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IDA	J:204747
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:320008
Cellular Component	GO:0099073	mitochondrion-derived vesicle	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	IDA	J:73105
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:207233
Cellular Component	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:132191
Cellular Component	GO:0032991	protein-containing complex	IDA	J:132191
Cellular Component	GO:0032991	protein-containing complex	IDA	J:132191
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0000151	ubiquitin ligase complex	IBA	J:265628
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:133213
Biological Process	GO:0070842	aggresome assembly	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0000422	autophagy of mitochondrion	ISO	J:155856
Biological Process	GO:0000422	autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0000422	autophagy of mitochondrion	IBA	J:265628
Biological Process	GO:1904881	cellular response to hydrogen sulfide	ISO	J:155856
Biological Process	GO:1905232	cellular response to L-glutamate	ISO	J:155856
Biological Process	GO:0097237	cellular response to toxic substance	ISO	J:164563
Biological Process	GO:0097237	cellular response to toxic substance	IDA	J:212811
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:85561
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:85561
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:85561
Biological Process	GO:0051583	dopamine uptake involved in synaptic transmission	IMP	J:85561
Biological Process	GO:0010994	free ubiquitin chain polymerization	ISO	J:164563
Biological Process	GO:0007612	learning	IMP	J:85561
Biological Process	GO:0007626	locomotory behavior	IMP	J:86377
Biological Process	GO:0007626	locomotory behavior	IMP	J:99163
Biological Process	GO:0007626	locomotory behavior	IMP	J:85561
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	ISO	J:155856
Biological Process	GO:0051646	mitochondrion localization	ISO	J:155856
Biological Process	GO:0099074	mitochondrion to lysosome transport	ISO	J:164563
Biological Process	GO:0000423	mitophagy	ISO	J:164563
Biological Process	GO:0000423	mitophagy	IGI	J:214528
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:86377
Biological Process	GO:0044828	negative regulation by host of viral genome replication	ISO	J:164563
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:186974
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IGI	J:117737
Biological Process	GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:198144
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:1903542	negative regulation of exosomal secretion	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0033132	negative regulation of glucokinase activity	ISO	J:73065
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:73065
Biological Process	GO:1905366	negative regulation of intralumenal vesicle formation	ISO	J:164563
Biological Process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO	J:164563
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:212811
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:153434
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:73065
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	IMP	J:171058
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ISO	J:155856
Biological Process	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:204747
Biological Process	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902283	negative regulation of primary amine oxidase activity	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:1904049	negative regulation of spontaneous neurotransmitter secretion	ISO	J:164563
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0042415	norepinephrine metabolic process	IMP	J:91487
Biological Process	GO:0042415	norepinephrine metabolic process	IMP	J:91487
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:155856
Biological Process	GO:1903599	positive regulation of autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:1903861	positive regulation of dendrite extension	IGI	J:219122
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0010636	positive regulation of mitochondrial fusion	ISO	J:164563
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	ISO	J:155856
Biological Process	GO:1901526	positive regulation of mitophagy	ISO	J:155856
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0051582	positive regulation of neurotransmitter uptake	ISO	J:164563
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:204747
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:1902530	positive regulation of protein linear polyubiquitination	IMP	J:198144
Biological Process	GO:1902530	positive regulation of protein linear polyubiquitination	ISO	J:164563
Biological Process	GO:1905477	positive regulation of protein localization to membrane	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010498	proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	IMP	J:171058
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	IMP	J:153434
Biological Process	GO:0070979	protein K11-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0085020	protein K6-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070585	protein localization to mitochondrion	ISO	J:155856
Biological Process	GO:0070585	protein localization to mitochondrion	IMP	J:204747
Biological Process	GO:0019538	protein metabolic process	IMP	J:89508
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IBA	J:265628
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:155856
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	IBA	J:265628
Biological Process	GO:0042053	regulation of dopamine metabolic process	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	ISO	J:155856
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	IGI	J:219122
Biological Process	GO:0010821	regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	IBA	J:265628
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IMP	J:86377
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	ISO	J:155856
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0031396	regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IPI	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IEP	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IMP	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IPI	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IMP	J:260099
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	IDA	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IDA	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IMP	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IPI	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IEP	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IDA	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IDA	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IMP	J:260099
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	IPI	J:260099
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:186974
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0001964	startle response	IMP	J:91487
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:85561
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:85561
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IBA	J:265628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23