GO Annotations Graph

• Symbol: Tfr2
• Name: transferrin receptor 2
• ID: MGI:1354956

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0039706	co-receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:117182
Molecular Function	GO:0004998	transferrin receptor activity	ISO	J:164563
Molecular Function	GO:0004998	transferrin receptor activity	TAS	J:60923
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:1990712	HFE-transferrin receptor complex	ISO	J:164563
Cellular Component	GO:1990712	HFE-transferrin receptor complex	IDA	J:117182
Cellular Component	GO:0016020	membrane	ISA	J:60923
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	IDA	J:250166
Cellular Component	GO:0098794	postsynapse	IDA	J:250166
Cellular Component	GO:0098794	postsynapse	IDA	J:250166
Biological Process	GO:0071281	cellular response to iron ion	ISO	J:164563
Biological Process	GO:0140298	endocytic iron import into cell	ISO	J:164563
Biological Process	GO:0140298	endocytic iron import into cell	IBA	J:265628
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	TAS	J:60923
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:193218
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:164563
Biological Process	GO:0090277	positive regulation of peptide hormone secretion	ISO	J:164563
Biological Process	GO:1903319	positive regulation of protein maturation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:250166
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:250166
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IEP	J:250166
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IMP	J:250166
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:250166
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:250166
Biological Process	GO:0010039	response to iron ion	ISO	J:164563
Biological Process	GO:0033572	transferrin transport	ISO	J:164563